The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR. The experiment was first described by Geoffrey Bodenhausen and D. J. Ruben in 1980. [1]

The HSQC (Heteronuclear Single Quantum Coherence) experiment is used to determine proton-carbon single bond correlations, where the protons lie along the observed F2 (X) axis and the carbons are along the F1 (Y) axis. An edited HSQC spectrum of …

Gained Information: The Heteronuclear Single Quantum Correlation (HSQC) NMR experiment is a proton-detected 2D experiment that shows you 1H / 13C one-bond connectivity. You will see your 1H spectrum as your direct F2 axis and your 13C spectrum as your indirect F1 axis.

2023年2月11日 · Hetereonuclear Single Quantum Coherence (HSQC) is used to determine the proton to carbon or heteroatom (often nitrogen) single bond correlations. It is also known as heteronuclear multiple quantum coherence (HMQC).

HSQC - Heteronuclear Multiple Quantum Correlation. This 2D experiment correlates the chemical shift of proton with the chemical shift of the directly bonded carbon. On the bottom axis is a proton spectrum and on the other is a carbon. Cross peaks give …

Heteronuclear Single Quantum Coherence (HSQC) is a technique used in NMR spectroscopy to simultaneously record 1H and 13C chemical shifts by coupling 1H nuclei with other NMR-active nuclei directly bonded to them, providing structural information in complex mixtures.

HSQC 1 H-C one-bond correlations: HSQC Preliminaries. For both 1H and 13C, you need a good power‐pw90 pair and you should have good values for both sw and tof for both nuclei. In short, you should have a beautiful calibrated 131H spectrum in one workspace

2024年8月31日 · 最后，利用二维核磁共振谱（如cosy、hsqc、hmbc）对图谱作进一步的指认，通过交叉峰分析建立氢核和碳核之间的直接连接关系，完成未知谱线的指认。 解析过程中，需要特别注意二维谱中相关峰的强度较弱及可能出现的假峰，确保结果的准确性。

1 H 13C Heteronuclear Single Quantum Coherence Spectroscopy (HSQC) or its multi-quantum counterpart (HMQC) are used to correlate the chemical shifts of protons (displayed on the F2 axis) to that of the carbon atom directly attached (reported on the F1 axis) utilizing the one-bond coupling 1JCH, generally set to ≈145 Hz to detect both anomeric (1...

多糖的结构解析中，hsqc二维核磁是开展糖苷键连接确认的基础谱图。 从有机物的HSQC解谱而言，代表的相连接的C-H相关，比如乙醇CH3-CH2-OH，其HSQC谱图中，甲基的质子和甲基碳有相交叉的信号，而亚甲基质子和亚甲基…