The proviruses of HIV-1 and HTLV-1 are transcribed into gRNA and unspliced and spliced mRNA. The surface glycoprotein, Env, is synthesized in the endoplasmic reticulum as the precursor polyprotein, gp160 (HIV-1) or gp66 (HTLV-1), and delivered to …

2022年1月14日 · So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes. HIV replication induces the apoptosis of CD4 lymphocytes, leading to the …

Differently from HIV-1, HTLV-1 virus spread relies mainly on vertical transmission (mitotic spread), while a role can be also played by horizontal transmission (infectious spread). In contrast with HIV-1 which kills target CD4+ cells, HTLV-1 infection is characterized by expansions and persistence of infected T cell clones that prompt the ...

HIV/HTLV-1 coinfection is associated with accelerated progression to AIDS and worse outcomes of HIV-related opportunistic infections. 5-7 Human T-cell lymphotropic virus type 1 induces HIV viral replication and the transition from M- to T-tropic HIV phenotype, which is often a marker of HIV disease progression. 8 In addition, compared to ...

2024年9月27日 · In this review, we present recent findings on the assembly mechanisms of Human T-cell leukemia virus type 1 and highlight key differences from HIV-1, focusing particularly on the molecular determinants of Gag–PM interactions and …

2024年11月11日 · Multiple studies have revealed co-infected patients with HTLV-2 and HIV-1. In this paper, we formulated a new mathematical model for the co-infection of HTLV-2 and HIV-1 in vivo. The HIV-1-specific B-cell response is included.

2013年12月23日 · In this review we have outlined the immune mediated mechanisms by which HTLVs affect HIV-1 disease in co-infected hosts. During co-infection with HIV-1, HTLV-2 modulates the cellular microenvironment favoring its own viability and …

2018年5月8日 · It's related to HIV, yet you've probably never heard of it: a virus called human T-cell leukemia virus type 1, or HTLV-1. But now, high rates of HTLV-1 in parts of Australia are prompting...

2022年4月29日 · HIV pre-exposure prophylaxis (HIV-PrEP) is effective in reducing the likelihood of HIV acquisition in HIV-negative people at high risk of exposure. Guidelines recommend testing for sexually transmitted infections (STIs) before starting, and periodically on PrEP, including bacterial infections, HIV, …

In this review, we discuss the epidemiological context of HIV-PrEP and HTLV-1 transmission; present current knowledge of antiretrovirals in relation to HTLV-1 transmission prevention; and identify knowledge gaps where data are required to inform the global public health measures to protect HIV-PrEP users from HTLV-1.