夏总平实验室揭示HTLV-1病毒蛋白Tax激活宿主NF-κB信号通路的 …
2016年4月18日 · 在HTLV-1的基因组上，除了编码逆转录病毒所必须的结构和功能蛋白以外，还编码着一系列的调节蛋白，包括Tax、Rex、HBZ等。 其中，最重要并且是研究最为广泛的，就 …
Mechanisms of Oncogenesis by HTLV-1 Tax - PMC - PubMed …
The HTLV-1 Tax oncoprotein interacts with a plethora of host cellular proteins to regulate viral gene expression and also promote the aberrant activation of signaling pathways such as NF …
Mechanisms of Oncogenesis by HTLV-1 Tax - PubMed
2020年7月7日 · The HTLV-1 Tax oncoprotein interacts with a plethora of host cellular proteins to regulate viral gene expression and also promote the aberrant activation of signaling pathways …
Molecular mechanisms of cellular transformation by HTLV-1 Tax
2005年9月5日 · Our current understanding is that Tax is the primary HTLV-1-encoded factor used by the virus to modulate cellular proliferation. During virus replication, the Tax protein is a …
Stratagems of HTLV-1 for persistent infection and the resultant ...
2025年3月16日 · The length of the HTLV-1 provirus is only approximately 9 kb in size.The HTLV-1 provirus encodes several regulatory (tax and rex) and accessory genes (p12, p13, p30, and …
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic …
2010年11月5日 · The HTLV-1 proto-oncogene Tax, a potent transcriptional activator of cellular and viral genes, is thought to play a pivotal role in the transforming properties of the virus by …
The HTLV-1 viral oncoproteins Tax and HBZ reprogram the …
2021年9月20日 · Tax and HBZ are two viral regulatory proteins encoded by the human T-cell leukemia virus type 1 (HTLV-1) via sense and antisense transcripts, respectively. Both …
The HTLV-1 Tax interactome - PMC - National Center for …
2008年8月14日 · Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these …
Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
2017年12月21日 · Two HTLV-1 genes, tax and HTLV-1 basic leucine zipper factor (HBZ), have been demonstrated to play important roles in HTLV-1 infectivity and the growth and survival of …
Dysregulation of the tumor suppressor Menin and its target Bach2 …
4 天之前 · The amount of HTLV-1 proviral DNA was determined using the following formula: copy number of HTLV-1 tax per 1 × 10 4 PBMCs = [(copy number of Tax)/(copy number of β − …