Conditional VHL knockdown may enhance the NO-VEGF axis and protect glomerular endothelial cells from HV GN, thereby providing resistance to injury of tubular epithelial cells and glomerular endothelial cells.

In this review, current knowledge of the Gn and Gc structures and their functions in virus cell entry and exit is summarized. During virus cell entry, the role of Gn and Gc in receptor binding has not yet been determined. Nevertheless, biochemical studies suggest that the subsequent virus-membrane fusion activity is accomplished by Gc.

Sep 15, 2020 · Here we report the X-ray structure of the metastable pre-fusion Gn H /Gc heterodimers of ANDV and Maporal virus (MAPV; an NWH closely related to ANDV) to 3.2- and 2.2-Å resolution, respectively. The ANDV complex required a stabilizing mutation in Gc to avoid a spontaneous conformational change into its post-fusion conformation despite bound Gn H.

Jan 24, 2019 · Our findings suggest that PUUV Gc is the driving factor of the targeting of Gc and Gn to the Golgi region, while Gn possesses a significantly stronger self-association potential.

Apr 14, 2011 · We have reported that tubular epithelial cell injury caused by renal ischemia−reperfusion is attenuated in conditional VHL knockout (VHL-KO) mice and also that induction of hypoxia-inducible factor (HIF) suppresses angiotensin II-accelerated Habu snake venom (HV) glomerulonephropathy in rats.

In control mice with HV GN, NO signals are completely attenuated throughout the kidney, especially in the glomeruli (control). However, in VHL-KO mice with HV GN, NO signals are still detected...

However, a role of the von Hippel-Lindau (VHL) protein in GN and mechanisms by which HV regulates the pathogenesis of GN remains unclear. Methods and results: Immunohistochemical analysis revealed that VHL is weakly expressed in the renal tubules alone; however, HV caused elevated VHL expression in the injured glomeruli including endothelial ...

The N-terminal Gn and C-terminal Gc have been suggested to be cleaved cotranslationally by cellular sig-nal peptidases (7). The interplay between Gn and Gc has a fundamental importance in HV assembly and budding (8, 9).

Feb 1, 2007 · Using a model of acute glomerulonephopathy induced by Habu snake venom (HV GN) (a glomerular endotheliumtargeted model), we have demonstrated that angiotensin II accelerates the formation of HV...

Feb 1, 2007 · The present study documents temporarily increased glomerular VEGF gene and protein expression during the healing of HSV GN, suggesting a potential role of VEGF in the repair of mesangiolytic ...