2022年1月19日 · Here we show that glucagon challenge impairs expression of HADHA. Liver-specific HADHA overexpression reversed hepatic gluconeogenesis in mice, while HADHA knockdown augmented glucagon...

HADHA is an 82.9 kDa protein composed of 763 amino acids. [6] [7] The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. The genes of the alpha and beta subunits of the mitochondrial trifunctional ...

2024年12月25日 · HADHA (Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha) is a Protein Coding gene. Diseases associated with HADHA include Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency and Mitochondrial Trifunctional Protein Deficiency 1.

2022年1月22日 · 该研究揭示了线粒体脂肪酸氧化酶HADHA以及酮体 β-羟基丁酸抑制肝脏糖异生紊乱的作用机制，为糖尿病的防治提供了潜在干预途径。

线粒体膜结合异质复合物由四个 α 和四个 β 亚基组成，α 亚基催化 3-羟基酰基辅酶 A 脱氢酶和烯酰辅酶 A 水合酶活性。 该基因的突变导致三功能蛋白缺乏症或 LCHAD 缺乏症。 线粒体三功能蛋白的 alpha 和 beta 亚基的基因在人类基因组中以头对头的方向彼此相邻。 [RefSeq 提供，2008 年 7 月] This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids.

In tumor tissues, the expression of HADHA is downregulated; the expression of HADHA is also significantly correlated with tumor grade, stage, size, metastasis and tumor-specific survival. Downregulation of HADHA expression is associated with poor tumor prognosis and HADHA is an independent prognostic factor.

编码的蛋白质在线粒体基质中发挥作用，催化直链 3-羟基酰基-CoA 的氧化，作为 β-氧化途径的一部分。 它的酶活性在中链脂肪酸中最高。 该基因的突变会导致一种形式的家族性高胰岛素血症性低血糖症。 人类基因组在 15 号染色体上包含该基因的相关假基因。 [RefSeq 提供，2010 年 5 月] This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family.

2020年2月7日 · We found direct downstream target of miR-612, hadha by RNA immunoprecipitation and sequencing. To explore its biological characteristic, potential molecular mechanism, and clinical relevance in HCC patients, we performed several in-vitro and in-vivo models, as well as human tissue chip.

HADHA knockdown increased the expression levels of HLA-G, MMP2, MMP9, and NCAD (P<0.01, P<0.05), and promoted the migration and invasion of HTR-8/SVneo cells (P<0.05). In addition, HADHA overexpression decreased the phosphorylation levels of PI3K and AKT (P<0.05) and inhibited the PI3K/AKT signaling pathway.

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit-alpha (HADHA) is part of the mitochondrial trifunctional protein (TFP), a crucial enzyme in long-chain fatty acid β-oxidation. Together with the four beta subunits (HADHB), HADHA forms the functional mitochondrial TFP.