HATU (Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine), or triethylamine to form amide bonds.

O- (7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | C10H15F6N6OP | CID 6409673 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

hatu，是一种常用的 多肽 缩合试剂，应用在 羧基 与 氨基 合成 肽键 的反应之中。 其系统命名为2-(7-氮杂 苯并三氮唑 )-N,N,N',N'- 四甲基脲 六氟磷酸 酯，英文名2-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate [1]

hatu是一种常用的多肽缩合试剂，应用在羧基与氨基合成肽键的反应之中，相对于其他类似缩合剂（如，hbtu）反应速度更快，不易消旋。利用hatu进行酰胺化反应，条件温和，产率高，很多大位阻的缩合剂也能反应，广泛应用于合成各种医药中间体。

N-Acylsulfonamide safety-catch linkers are versatile tools in solid-phase organic synthesis because of their stability. This stability necessitates linker activation prior to compound cleavage. Here, we demonstrate that the N-acylsulfonamide group can react with a pi-allyl palladium complex and that these.

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HATU; Product No: A1797; CAS RN: 148893-10-1; Purity: >98.0%(HPLC); Synonyms: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate; Appearance: White to Almost white powder to crystaline, min. 98.0 area%; contact TCI for more

Example procedures for the conversion of an amine to an amide using HATU.

2022年2月10日 · HATU, 2-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, is a commonly used condensation reagent and is widely used in the synthesis of amide bonds. HATU promotes the formation of amide bonds by activating the carboxyl group.

2024年7月3日 · HATU was a third-generation coupling reagent with the ability to decrease racemization. HATU causes amine acylation or the formation of an amide bond. In addition to nucleophiles, it is employed in peptide cyclization. HATU catalyzes the …