2024年12月25日 · HBA2 (Hemoglobin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with HBA2 include Hemoglobin H Disease and Alpha-Thalassemia. Among its related pathways are Erythrocytes take up carbon dioxide and release oxygen and …

The HBA2 gene provides instructions for making a protein called alpha-globin. This protein is also produced from a nearly identical gene called HBA1. These two alpha-globin genes are located close together in a region of chromosome 16 known as the alpha-globin locus.

Hemoglobin, alpha 2[5] also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin. [6][7] The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2 - HBA1 - HBQ1 -3'.

2025年2月9日 · Gene target information for HBA2 - hemoglobin subunit alpha 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

alpha-2 (HBA2) 和 alpha-1 (HBA1) 编码序列是相同的。 这些基因在 5' 非翻译区和内含子上略有不同，但在 3' 非翻译区上却有显着差异。 两条 α 链加上两条 β 链构成 HbA，在正常成人生活中约占总血红蛋白的 97%； alpha 链与 delta 链结合构成 HbA-2，它与 HbF (胎儿血红蛋白) 一起构成成人血红蛋白的剩余 3%。 α 地中海贫血是由每个 α 基因的缺失以及 HBA2 和 HBA1 的缺失引起的；一些非缺失性 α 地中海贫血也有报道。 [RefSeq 提供，2008 年 7 月]

HbA2 , a tetramer of α- and δ-globin chains, provides a diagnostic clue to the presence of β-thalassaemia trait. This minor haemoglobin, which forms about 2-3% of the total, has no known physiological role, but has the interesting property of preventing polymerization of …

Novel point mutation of the alpha2-globin gene (HBA2) and a rare 2.4 kb deletion of the alpha1-globin gene (HBA1), identified in two chinese patients with Hb H disease.

HGNC Approved Gene Symbol: HBA2. Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38) : 16:172,876-173,710 (from NCBI) The HBA1 (141800) and HBA2 genes encode identical 141-amino acid proteins (summary by Michelson and Orkin, 1983).

2024年12月10日 · Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of …

2016年9月14日 · The HBA2 gene provides instructions for making a protein called alpha-globin. This protein is also produced from a nearly identical gene called HBA1. These two alpha-globin genes are located close together in a region of chromosome 16 known as the alpha-globin locus.