Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the HBB gene, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). [5]

2024年12月25日 · HBB (Hemoglobin Subunit Beta) is a Protein Coding gene. Diseases associated with HBB include Sickle Cell Disease and Beta-Thalassemia, Dominant Inclusion Body Type. Among its related pathways are Innate Immune System and Erythrocytes take up carbon dioxide and release oxygen.

2025年3月17日 · Gene target information for HBB - hemoglobin subunit beta (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The HBB gene provides instructions for making a protein called beta-globin. Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells.

α (HBA) 和β (HBB) 位点决定了成人血红蛋白 Hb A 中两种多肽链的结构。 正常的成人血红蛋白四聚体由两条 α 链和两条 β 链组成。 突变的 β 珠蛋白会导致镰状细胞性贫血。 缺乏β链会导致β-零地中海贫血。 可检测到的 β 珠蛋白数量减少会导致 β 加地中海贫血。 β-珠蛋白簇中基因的顺序是 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'。 [RefSeq 提供，2008 年 7 月]

Gene ID: 15129, updated on 11-Feb-2025. This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues.

β-thalassemia is a hereditary hematological disease caused by over 350 mutations in the β-globin gene (HBB). Identifying the genetic variants affecting fetal hemoglobin (HbF) production combined with the α-globin genotype provides some prediction of ...

血红蛋白亚基β （Beta Globin， β-珠蛋白， 血红蛋白β， 血红蛋白β）是 Globin 蛋白质，由 HBB 基因，与alpha globin一起（HBA），构成最常见的形式 血红蛋白 在成年人中， 血红蛋白a （HBA）。 [5] 它长147个氨基酸，分子量为15,867 da。 正常成人人类HBA是一个 异驱动器 由两个α炼和两个β链组成。 HBB由 HBB 基因开 人类染色体11。 基因中的突变产生几种蛋白质的变异，与遗传疾病（例如 镰状细胞性贫血症 和 βthalassya，以及有益的特征，例如 对疟疾的遗传 …

2025年1月4日 · The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.

They are C-shaped and resembles a sickle. These stiffer red blood cells can led to microvascular occlusion thus cutting off the blood supply to nearby tissues. DISEASE: Defects in HBB are the cause of beta-thalassemia dominant inclusion body type (B-THALIB) [MIM:603902].