在小鼠中的表达研究表明，HBB2由肺泡上皮细胞和内皮细胞产生，并在携带不可检测转移的小鼠中上调。 我们的工作提出了HBB作为治疗诊断分子的新功能：一种固有的抗转移因子，具有潜在的抗癌药作用和生物标志物，可指示存在临床上不可检测的转移灶。 癌症研究；77（1）；14-26。 （c）2016年美国机修协会（AACR）。 The Beta Subunit of Hemoglobin (HBB2/HBB) Suppresses Neuroblastoma Growth and Metastasis.

2017年1月1日 · Peptide mapping in the beta subunit of human hemoglobin (HBB) defined a short C-terminal region (termed Metox) as responsible for activity. In tissue culture, both HBB and murine HBB2 mediated growth arrest and apoptosis of lung-metastasizing neuroblastoma cells, along with a variety of other human cancer cell lines.

2024年12月25日 · HBB (Hemoglobin Subunit Beta) is a Protein Coding gene. Diseases associated with HBB include Sickle Cell Disease and Beta-Thalassemia, Dominant Inclusion Body Type. Among its related pathways are Innate Immune System and Erythrocytes take up carbon dioxide and release oxygen.

2017年1月2日 · Peptide mapping in the beta subunit of human hemoglobin (HBB) defined a short C-terminal region (termed Metox) as responsible for activity. In tissue culture, both HBB and murine HBB2 mediated growth arrest and apoptosis of lung-metastasizing neuroblastoma cells, along with a variety of other human cancer cell lines.

α (HBA) 和β (HBB) 位点决定了成人血红蛋白 Hb A 中两种多肽链的结构。 正常的成人血红蛋白四聚体由两条 α 链和两条 β 链组成。 突变的 β 珠蛋白会导致镰状细胞性贫血。 缺乏β链会导致β-零地中海贫血。 可检测到的 β 珠蛋白数量减少会导致 β 加地中海贫血。 β-珠蛋白簇中基因的顺序是 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'。 [RefSeq 提供，2008 年 7 月]

2024年6月28日 · The adult hemoglobin is a heterotetramer of two alpha chains and two beta chains, and functions in the transport of oxygen from the lungs to various peripheral tissues. This gene is expressed in red blood cells and encodes the beta polypeptide chain.

2007年1月23日 · Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.

2024年12月2日 · Gene ID: 100009084, updated on 2-Dec-2024. The adult hemoglobin is a heterotetramer of two alpha chains and two beta chains, and functions in the transport of oxygen from the lungs to various peripheral tissues. This gene is expressed in red blood cells and encodes the beta polypeptide chain.

Here we report the isolation and characterization of the beta subunit of hemoglobin as a lung-derived antimetastatic factor. Peptide mapping in the beta subunit of human hemoglobin (HBB) defined a short C-terminal region (termed Metox) as responsible for activity. In tissue culture, both HBB and murine HBB2 mediated growth ar

Conclusion: HBB can serve as a novel biomarker for the diagnosis and monitoring of lung cancer, regulating cell proliferation via the ERK1/2 pathway and playing a pivotal role in the oncogenesis and progression of the disease. Keywords: hemoglobin beta, lung …