Here’s how normal cardiac metabolism works: adenosine triphosphate (ATP) is the primary energy source for the heart and is used to fuel the heart’s activities – 60-70% of ATP is used …

2021年5月14日 · Any disruptions in the energy metabolic pathways that produce ATP, or in oxygen supply to the heart, can have catastrophic consequences on cardiac function. As a …

Characterizing cardiac metabolism in heart failure revealed several metabolic alterations termed metabolic remodeling, ranging from changes in substrate utilization to mitochondrial …

2023年5月26日 · Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a continuous supply of ATP in large quantities, the role of fuel metabolism in the heart …

2024年12月11日 · Generally, patients with heart failure have decreased ATP production in cardiac myocytes as well as other abnormalities in cardiac metabolism, including cell death. …

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about …

2009年12月4日 · The human heart contains approximately 700 mg of ATP, enough to fuel one heartbeat per second for ten seconds, and needs a minimum of 6,000 grams of ATP per day …

Figure 1.1 is a cartoon summarizing the story of ATP and the Heart. On the right are the primary ATP utilizing reactions: myosin ATPase in the myofibril, the Ca2+-ATPase in the sarcoplasmic …

The very high energy demand of the heart is primarily met by adenosine triphosphate (ATP) production from mitochondrial oxidative phosphorylation, with glycolysis providing a smaller …

2024年7月2日 · The levels of ATP and free ADP (<20 μM, i.e., >100× less than ATP; note that up to 90% of ADP is bound to actin filaments) are defended by the heart to maintain constant the …