Hepatic veno-occlusive disease (VOD) or veno-occlusive disease with immunodeficiency is a potentially life-threatening condition in which some of the small veins in the liver are obstructed. It is a complication of high-dose chemotherapy given before a bone marrow transplant or excessive exposure to hepatotoxic pyrrolizidine alkaloids.

2019年5月4日 · Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease (VOD), is a distinctive and potentially fatal form of hepatic injury that occurs predominantly, if not only, after drug or toxin exposure.

Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and ascites, occurring after high-dose chemotherapy, hematopoietic stem cell transplantation (HSCT) and, less commonly, other conditions.

肝小静脉闭塞病（hepatic veno-occlusive disease，VOD） 是由于某些原因所致肝小叶中央静脉和小叶下静脉等小静脉内膜炎和纤维化，而导致管腔狭窄、广泛闭塞，甚至引起肝细胞坏死、纤维化的一种血管疾病。

2024年1月23日 · HSOS可发生于接受骨髓造血干细胞移植清髓处理、放射/化学治疗和摄入含吡咯生物碱药物的人群，常见临床表现为腹胀、肝区胀痛、腹水、黄疸、肝大等。 针对不同病因，HSOS的诊断标准也不相同，需要与其他药物性肝病、肝静脉流出道梗阻等疾病相鉴别。 去纤苷和低分子肝素分别对造血干细胞和吡咯生物碱相关的HSOS具有治疗作用，奥沙利铂化疗导致的HSOS目前尚无有效治疗药物。

Hepatic veno-occlusive disease (VOD), increasingly referred to as sinusoidal obstruction syndrome, is a well-recognized complication of hematopoietic stem cell transplantation and contributes to considerable morbidity and mortality.

Hepatic veno-occlusive disease (VOD) or sinusoidal obstructive syndrome (SOS) is a disorder characterised by obstruction of small intra-hepatic venules and damage to the surrounding centrilobular hepatocytes and sinusoids. It occurs principally as a complication of chemo-irradiation therapy, particularly following BMT.

2023年8月12日 · Veno-occlusive disease or sinusoidal obstruction syndrome of the liver (VOD/SOS) is a major, potentially fatal complication of hematopoietic stem cell transplantation,...

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a major complication of hematopoietic stem cell transplantation and it carries a high mortality. Prophylaxis for hepatic VOD is commonly given to transplant recipients from the start of conditioning through the early weeks of transplant.

2004年11月17日 · Definition: Hepatic VOD consists of occlusive fibrosis of small intrahepatc veins: centrilobular and sublobular venules. Lager veins and those affected by Budd-Chiari syndrome are spared.