1994年11月21日 · The using of 2-CTC resin allows to keep acid-labile functional groups intact, since the removal of amino acid sequence from the resin proceeds under mild conditions (in this case DCM/TFA...

2022年10月28日 · 为了更加快速的，操作更加方便的，同时能够最小化消旋的把全保护的多肽片段从CTC树脂上裂解下来，这里我们使用了HFIP（6-氟异丙醇）：DCM=1:4的混合物来进行裂解。

2024年4月28日 · Employing DCM/HFIP (v / v) as solvent, the metal-free mediated reactions could proceed smoothly at room temperature without any catalyst or promoter, and providing various triarylmethanes in moderate to excellent yields. The transformation reveals a broad substrate scope and good group tolerance.

2024年3月4日 · In the past 5 years, hexafluoroisopropanol (HFIP) has been used as a unique solvent or additive to enable challenging transformations through substrate activation and stabilization of reactive intermediates. In this Review, we aim at describing difunctionalization processes which were unlocked when HFIP was involved.

Add acetic acid (0.5 mL per gram of resin), N-methylmorpholine (2 mL per gram of resin), and Pd (PPh 3) 4 (3 equivalents based on resin substitution). Shake the mixture at room temperature for 12 hours. Filter and wash the deprotected resin product with dichloromethane (DCM). Removal of Dde and ivDde Groups (Hydrazine Method)

2024年3月22日 · 六氟异丙醇 (HFIP)是一种极性强氢键供给溶剂，由于其稳定离子物质、转移质子和参与一系列其他分子间相互作用的能力，在有机合成中具有多种用途。

2022年6月1日 · A hexafluoroisopropanol (HFIP)-catalyzed highly diastereoselective formal [4 + 2] cyclization between ortho-hydroxyphenyl para -quinone methides and difluoroenoxysilanes is developed.

The Mtt group can be removed from the side chain of lysine or ornithine using 1% TFA in DCM 14 or with DCM/HFIP/TFE/TES (6.5:2:1:0.5) (Method 2), allowing selective removal in the presence of other side-chain protecting groups which require up to 95% TFA for removal.

Download scientific diagram | Molar conversion of PTAD-tyrosine conjugate products (6a-f) using HFIP/DCM solvent system, as determined via 1 H-NMR. from publication: Novel Strategy for...

2024年1月26日 · 英国雷丁大学的研究人员发现，使用0.1 N HCl/HFIP或者0.1 N HCl/TFE可以有效将多肽从CTC树脂上裂解下来，并且能够有效脱除Pbf (Arg侧链保护基团)、tBu (羟基和羧基保护基团)、Trt（酰胺、咪唑或巯基保护基团）和Boc（氨基保护基团）等主要多肽固相合成的侧链保护基 …