2025年3月7日 · 六氟异丙醇 (简称：HFIP)是一种重要的含氟精细化学品，可用于制备含氟表面活性剂、含氟乳化剂、含氟医药等多种含氟化学品，或者作为良好溶剂。 可提高醚束缚炔基二烯的铑 (I)-催化 [4+2]分子内环加成反应和炔基乙烯基环丙烷的 [5+2]环加成反应的效率；液相肽化学溶剂；用于肽和肽中间体的高溶性溶剂；用于多种聚合物的分析。 六氟异丙醇（HFIP）是一种新型的含氟化合物，是一种高极性的溶剂，与水和许多有机溶剂很容易混合，热稳定性好，并且对于 …

It is also relatively acidic, with a pKa of 9.3, comparable to that for phenol. [1] It is classified as a hard Lewis acid and its acceptor properties are discussed in the ECW model. [3] [4] Hexafluoro-propan-2-ol is a speciality solvent for organic synthesis, particularly for reactions involving oxidations and strong electrophiles.

2017年10月27日 · In short, the stronger the acid, the smaller the pKa value and strong acids have weak conjugate bases. pKa values describe the point where the acid is 50% dissociated (i.e. deprotonated). Below are tables that include determined pKa values for various acids as determined in water, DMSO and in the gas Phase.

2025年1月27日 · Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample.

2024年3月22日 · kopple 等人进一步研究了 hfip 作为肽偶联溶剂的用途，并确定活性羧基组分的溶剂分解产生 hfip 酯，可用作肽偶联的温和酰化剂。尽管 hfip 是溶解肽和切割酸敏感保护基团的合适溶剂，但与二甲氧基乙烷 (dme) 或n , n-二甲基甲酰胺 (dmf)相比，hfip 中的肽偶联要慢得多。

六氟异丙醇（英語： Hexafluoroisopropanol ，缩写HFIP，全称：1,1,1,3,3,3-六氟丙-2-醇）是一种含氟有机化合物，化学式为(CF 3) 2 CHOH，属于氟代醇类，常作为有机溶剂 [1] 。

2020年9月22日 · The relevant characteristics that have made HFIP a key solvent in electrosynthesis, such as pKa, viscosity, boiling point and dielectric constant are summarized in Table I. Its high dielectric ( ε = 16.7) compared to other organic solvents is noteworthy.

HFIP has recently become a very popular solvent or additive with applications across the spectrum of chemistry. It possesses a wide range of interesting and unique properties. Uncovering the...

pKa values of 231 acids in acetonitrile, ranging from hydrogen iodide (2.8) and indole (32.57) and covering almost 30 orders of magnitude. This is the revised and significantly extended version of our pKa scale of acids in MeCN.

采用液相催化加氢法还原hfa制备hfip，研究结果表明，在1%催化剂用量,100℃、1.0mpa的反应条件下，反应时间为22 h时hfa转化率为98.87%，还原选择性为97.87%。