2019年2月14日 · Hepatocyte growth factor (HGF) plays an important role in cancer progression via phosphorylation of MET (c-met proto-oncogene product, receptor of HGF). HGF-zymogen (pro-HGF) must be processed for activation by HGF activators including matriptase, which is a type II transmembrane serine protease and the most efficient activator.

Resolvin D1 altered the cytotoxicity of P. gingivalis supernatant on HGFs. Resolvin D1 significantly reduced GRO, marginally reduced MCP-1, and marginally increased TGF-β1 from P. gingivalis-treated HGFs, which could alter the ability of P. gingivalis to induce inflammation.

We now have evidence that a four-kringle-containing antagonist for HGF, HGF/NK4 inhibits invasion of tumors in vivo, as well as in vitro. HGF/NK4 competitively inhibited the binding of HGF...

一、HGF/MET信号通路核心生理功能. 1. 促进细胞增殖与存活. 激活抗凋亡蛋白（如BCL-2、MCL-1），上调细胞周期蛋白（如Cyclin D1、CDK4）表达。 2. 诱导细胞迁移与侵袭

Hepatocyte growth factor (HGF), a ligand for Met tyrosine kinase, is a mesenchyme- or stroma-derived multipotent factor that regulates the growth, motility, and morphogenesis of various types of cells. During lung development, Met/HGF receptor mRNA was localized in lung epithelial cells, whereas HGF …

How SAM regulates hepatocyte growth is unclear, but because SAM blocks hepatocyte growth factor (HGF)-induced cyclin D1 expression and DNA synthesis without affecting HGF-induced extracellular signal-regulated kinase phosphorylation, the mitogen-activated protein kinase (MAPK) pathway is probably not the target.

研究团队将从手术获得的肝祖细胞进行体外培养，通过添加重组人肝细胞生长因子（HGF）等细胞因子，成功衍生出肝脏类器官（HLOs），这一模型为探究NAFLD的发病机制提供了有力的工具。 研究发现，雌激素驱动的ER-α与下游配体的结合可促进高遗传风险变体PNPLA 3 p.I148M在肝细胞内脂滴中的合成和蓄积，这一发现揭示了雌激素在NAFLD发病机制中的重要作用。 代谢功能障碍相关脂肪肝病（MASLD）是一类进行性疾病，其肝再生机制已在动物模型内得到了研究，不 …

肝细胞生长因子 (hgf)，也是分散因子 (sf)，是一种旁分泌细胞生长、运动和形态形成因子。 它由间充质细胞和靶细胞分泌，主要作用于上皮细胞和内皮细胞，但也作用于造血祖细胞和 T 细胞。

2002年2月18日 · In the present study we demonstrate that HGF/SF stimulates cyclin D1 expression and subsequent proliferation of melanoma cells through the ATF-2 transcription factor. Moreover, p38 kinase and...

2014年10月10日 · HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances.