研究团队将从手术获得的肝祖细胞进行体外培养，通过添加重组人肝细胞生长因子（HGF）等细胞因子，成功衍生出肝脏类器官（HLOs），这一模型为探究NAFLD的发病机制提供了有力的工具。 研究发现，雌激素驱动的ER-α与下游配体的结合可促进高遗传风险变体PNPLA 3 p.I148M在肝细胞内脂滴中的合成和蓄积，这一发现揭示了雌激素在NAFLD发病机制中的重要作用。 代谢功能障碍相关脂肪肝病（MASLD）是一类进行性疾病，其肝再生机制已在动物模型内得到了研究，不 …

肝细胞生长因子（hepatocyte growth factor，HGF）作为一种间充质干细胞来源的生长因子，于1984年在部分肝切除成年大鼠的血清中被首次发现，因其为肝细胞的有效促分裂原，得名“肝细胞生长因子”[1]。

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

HGF/c-Met 信号轴以旁分泌的方式参与上皮器官的发育，发挥上皮的再生作用，并促进许多器官纤维化的消退。 此外，HGF/c-Met 信号通路与癌症、神经元和免疫生物学相关。

2024年12月25日 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

2015年4月1日 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

A structure-activity relationship study of human HGF was performed by functional analysis of HGF substitution and deletion variants. Analysis of HGF variants was accomplished by defining their ability to induce DNA synthesis on hepatocytes in primary culture and to compete with wild-type HGF for binding to a soluble form of the HGF receptor.

Definition: Hepatocyte growth factor (HGF), also knownasscatter factor (SF),is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine …

2006年3月14日 · The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the multidomain structure and proteolytic mechanism of activation of plasminogen and other complex serine proteinases. HGF/SF, however, has no enzymatic activity. Instead, it controls the growth, morphogenesis, o …