Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

肝细胞生长因子（hepatocyte growth factor，HGF）作为一种间充质干细胞来源的生长因子，于1984年在部分肝切除成年大鼠的血清中被首次发现，因其为肝细胞的有效促分裂原，得名“肝细胞生长因子”[1]。

肝细胞生长因子（hgf）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现hgf还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发生的多功能因子。

2015年4月1日 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

Hepatocyte growth factor (HGF, also known as scatter factor) is one example of such a pleiotropic factor which is able to induce a variety of responses in...

肝细胞生长因子 (HGF，又称 Scatter Factor) 是一类具有血管生成能力的因子。HGF最初被发现为上皮细胞的成纤维细胞源性细胞动力因子。它由间充质细胞、成纤维细胞和平滑肌细胞合成。

2011年1月4日 · Using a gene knock-out/knock-in approach and sterotaxic injections of HGF or neutralizing antibody into the striatum in mice reveals the critical role of HGF in the development of the nervous systems. 31 HGF functions as an axonal chemoattractant for spinal motor neurons and for the projection of motor neurons to limb muscle. 32 In addition ...

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progressi …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine …

该基因编码的蛋白质与肝细胞生长因子受体结合，可调节多种细胞和组织类型的细胞生长、细胞运动和形态发生。 可变剪接导致多个转录本变体，其中至少一个编码前原蛋白，该前原蛋白经过蛋白水解加工产生 alpha 和 beta 链，形成成熟的异二聚体。 该蛋白由间充质细胞分泌，在主要为上皮来源的细胞上充当多功能细胞因子。 这种蛋白质还在血管生成、肿瘤发生和组织再生中发挥作用。 虽然编码的蛋白质是丝氨酸蛋白酶肽酶 S1 家族的成员，但它缺乏肽酶活性。 该基因的突变与 …

Hepatocyte growth factor (HGF) is a mesenchyme-derived mitogen that also stimulates cell migration, and branching and/or tubular morphogenesis of epithelial and endothelial cells. In the present study, we tested the hypothesis that simultaneous administration of HGF and VEGF would synergistically promote new blood vessel formation.

2010年12月6日 · Hepatocyte growth factor (HGF) is a pleiotropic factor, which induces cellular motility, survival, proliferation, and morphogenesis, depending upon the cell type. In the...

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor internalization and degradation.

2022年3月17日 · Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue regeneration of injured organs. HGF is sequestered by heparin-like protein in its inactive form and is widespread in t …

Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis. Keywords: signaling pathways, tyrosine kinase receptor, protein–protein interaction, SH2 domain, post translational modification, signal transduction. 1.

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.

2016年8月24日 · Hepatocyte growth factor (HGF) has important roles in the cell and tissue repairment and regeneration. Here we investigated the enhanced effects of HGF-modified MSCs on...

HGF is a potent inhibitor of cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 through both autocrine and paracrine Epstein-Barr virus-independent pathways. HGF increased the motogenesis and invasiveness of hepatoblasts, but not of human adult hepatocytes, via phosphorylation of extracellular signal-regulated kinase (ERK) 1/2.

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue regeneration of injured organs. HGF is sequestered by heparin-like protein in its inactive form and is widespread in the extracellular matrix of most tissues.

2017年8月25日 · Here, we show that Arf6 plays an important role in HGF-stimulated hepatocyte proliferation and liver regeneration through the phosphatidylinositol 4,5-bisphosphate (PIP2)-producing enzyme PIP5K1A.