2020年6月4日 · Overexpression of the HGF/MET axis along with p53 attenuation may transform neural stem cells into GSCs, resulting in GBM formation in mice. These tumors are primarily driven by the MET RTK pathway activation and are sensitive to MET TKIs.

2020年6月4日 · In this study, we show that overexpression of HGF/MET, along with p53 suppression, induced de novo glioma formation in mice. These tumors infiltrate the brain and the perivascular spaces, are mitotically active, and show intrinsic, geographic necrosis and neoangiogenesis, pathological hallmarks that recapitulate human GBM histology.

2021年8月21日 · The results demonstrated an efficient and straightforward mouse lymphomagenesis model. By weekly injection of pure IGF2 and HGF into the mammary fat pad in p53-null mice, tumorigenesis could be achieved by seven weeks in two-third of the mice. IGF2 is the growth hormone specifically for the development of the fetus and ovarian follicle 33-35.

2021年8月21日 · Here, we showed human ovulatory follicular fluid (FF) largely promotes lymphomagenesis in Trp53-/- mice at earlier ages. Meanwhile, we clarified that IGF2 and HGF are important cell transforming factors within FF.

2024年11月19日 · The co-expression of p16 and α-SMA in hypoxic HK-2 cells confirmed the anti-senescent effect of hUC-MSCs-derived HGF (Fig. 6C). P53 and PKA are upregulated during chronic hypoxia and reversed by MSCs treatment.

2001年1月1日 · We have investigated the ability of wild-type p53 and a non-DNA binding p53 mutant to activate the hepatocyte growth factor/scatter factor (HGF/SF) promoter using chloramphenicol acetyltransferase reporter constructs. We also used deletion sequences of the HGF/SF promoter to identify which regions, if any, were responsible for p53 binding.

2016年4月15日 · p53是Met依赖性细胞运动和侵袭的重要调节剂。 目前的研究表明，用肝星状细胞（HSC）分泌的HGF处理2种HCC细胞系Hep3B和HepG2具有不同的侵袭能力。 我们发现HGF促进了Hep3B细胞的侵袭和迁移以及上皮-间质转化（EMT）的发生，因为Hep3B缺乏p53，导致c …

Current studies have indicated both positive and negative roles for the hepatocyte growth factor (HGF)/c-met receptor signaling system in tumor development. Recently, we have shown that HGF has the capacity to induce both growth inhibition and programmed cell death in aflatoxin-transformed (AFLB8) r …

2024年3月13日 · p53-deficient MPNSTs exhibited increased baseline MET activation suggesting that p53 loss disinhibits amplified MET signaling, an effect that is exaggerated in response to HGF. To determine...

2013年11月4日 · Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the physiological conditions. p53, a transcription factor, suppresses the cell proliferation by expressing p21 …