Overexpression of HGF/MET axis along with p53 inhibition
2020年6月4日 · Overexpression of the HGF/MET axis along with p53 attenuation may transform neural stem cells into GSCs, resulting in GBM formation in mice. These tumors are primarily …
Overexpression of HGF/MET axis along with p53 inhibition …
2020年6月4日 · In this study, we show that overexpression of HGF/MET, along with p53 suppression, induced de novo glioma formation in mice. These tumors infiltrate the brain and …
Insuline-Like Growth Factor-2 (IGF2) and Hepatocyte Growth Factor (HGF …
2021年8月21日 · The results demonstrated an efficient and straightforward mouse lymphomagenesis model. By weekly injection of pure IGF2 and HGF into the mammary fat …
Insuline-Like Growth Factor-2 (IGF2) and Hepatocyte Growth Factor (HGF …
2021年8月21日 · Here, we showed human ovulatory follicular fluid (FF) largely promotes lymphomagenesis in Trp53-/- mice at earlier ages. Meanwhile, we clarified that IGF2 and HGF …
MSCs-derived HGF alleviates senescence by inhibiting unopposed ...
2024年11月19日 · The co-expression of p16 and α-SMA in hypoxic HK-2 cells confirmed the anti-senescent effect of hUC-MSCs-derived HGF (Fig. 6C). P53 and PKA are upregulated during …
Wild-type but not mutant p53 activates the hepatocyte growth …
2001年1月1日 · We have investigated the ability of wild-type p53 and a non-DNA binding p53 mutant to activate the hepatocyte growth factor/scatter factor (HGF/SF) promoter using …
肝星状细胞通过p53调控的HGF / c-Met信号通路促进肝癌细胞侵袭 …
2016年4月15日 · p53是Met依赖性细胞运动和侵袭的重要调节剂。 目前的研究表明，用肝星状细胞（HSC）分泌的HGF处理2种HCC细胞系Hep3B和HepG2具有不同的侵袭能力。 我们发 …
HGF-mediated apoptosis via p53/bax-independent pathway
Current studies have indicated both positive and negative roles for the hepatocyte growth factor (HGF)/c-met receptor signaling system in tumor development. Recently, we have shown that …
p53 modulates kinase inhibitor resistance and lineage ... - Nature
2024年3月13日 · p53-deficient MPNSTs exhibited increased baseline MET activation suggesting that p53 loss disinhibits amplified MET signaling, an effect that is exaggerated in response to …
Induction of p53-Dependent p21 Limits Proliferative Activity of …
2013年11月4日 · Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the physiological …