2018年11月1日 · HGFAC is a coagulation factor XII-like serine endopeptidase that circulates in the plasma as a zymogen (proHGFAC). Thrombin, kallikrein-related peptidase (KLK)-4 or KLK-5 efficiently activates proHGFAC. The activated HGFAC cleaves proHGF at Arg494-Val495, resulting in the formation of the active disulfide-linked heterodimer HGF.

Hepatocyte growth factor (HGF, also known as scatter factor) is one example of such a pleiotropic factor which is able to induce a variety of responses in...

2010年4月26日 · Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor/scatter factor. Hepatocyte growth factor/scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its receptor, MET.

研究团队将从手术获得的肝祖细胞进行体外培养，通过添加重组人肝细胞生长因子（HGF）等细胞因子，成功衍生出肝脏类器官（HLOs），这一模型为探究NAFLD的发病机制提供了有力的工具。 研究发现，雌激素驱动的ER-α与下游配体的结合可促进高遗传风险变体PNPLA 3 p.I148M在肝细胞内脂滴中的合成和蓄积，这一发现揭示了雌激素在NAFLD发病机制中的重要作用。 代谢功能障碍相关脂肪肝病（MASLD）是一类进行性疾病，其肝再生机制已在动物模型内得到了研究，不 …

Endogenous HGF is required for self-repair of injured livers, kidneys, lungs and so on. In addition, HGF exerts protective effects on epithelial and non-epithelial organs (including the heart and brain) via anti-apoptotic and anti-inflammatory signals.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that promotes cell proliferation, motility, survival, and morphogenesis. HGF binds to its c-Met tyrosine kinase receptor and triggers signal transduction that protects cells against apoptosis and enhances cell …

2015年4月1日 · HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function.

肝细胞生长因子 (hgf)，也是分散因子 (sf)，是一种旁分泌细胞生长、运动和形态形成因子。 它由间充质细胞和靶细胞分泌，主要作用于上皮细胞和内皮细胞，但也作用于造血祖细胞和 T 细胞。

2018年8月30日 · HGF overexpression was able to compensate for the negative effects related to the absence of IRS2, by normalizing β-cell mass and improving glucose homeostasis in the context of IR . Taken together, these findings indicate that HGF could be employed as a regenerative factor in the treatment of diabetes.