HGF receptor is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its …

We review here Met structure and function, the basic properties of HGF/Met pathway antagonists now in preclinical and clinical development, as well as the latest clinical trial results.

2024年12月25日 · Mesenchymal Epithelial Transition MET is a prototypical receptor tyrosine kinase. Its ligand is Hepatocyte Growth Factor (HGF). MET alterations are drivers of human …

Hepatocyte growth factor (HGF) was originally reported in 1984 to be a mitogenic protein for mature hepatocytes in primary culture. The primary structure of HGF became evident with …

The HGF receptor (MET) is a prototypal tyrosine kinase receptor which plays a key role in the interaction between mesenchyme and epithelia during embryogenesis and tissue homeostasis …

c-Met，也称为酪氨酸蛋白激酶Met或肝细胞生长因子受体（HGFR），是人类中由MET基因编码的蛋白，具有酪氨酸激酶活性。 初级单链前体蛋白在翻译后被切割以产生α和β亚基，其被二硫 …

Our results indicate that HGF and HGFR gene expression is inducible and their expression is orchestrated in stromal and epithelial cells, respectively, by extracellular signals derived from …

Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding. The …

肝细胞生长因子（HGF）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现HGF还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发 …

Hepatocyte growth factor (HGF) exhibits mitogenic and/or motogenic activities for a variety of cells (see for review Matsumoto and Nakamura, 1992). Structurally, it has similarities to kringle …