Modulation of stemness in a human normal intestinal epithelial crypt ...
2014年4月1日 · HIEC cells are normal non-immortalized human intestinal epithelial crypt cells. Short term activation of the WNT pathway induces expression of stem cell markers. Co …
The development of a functional human small intestinal ... - AAAS
2021年6月2日 · We developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable hIEC progenitors and a functional hIEC monolayer …
Lipopolysaccharide modulation of normal enterocyte turnover by …
Results are reported as the mean (SEM) of triplicate samples. Significance was established at 95%, and determined by Student’s t test for non-paired values, and the Mann-Whitney U test …
Evaluation of Caco-2 and human intestinal epithelial cells as
In the HIEC cells of human embryonic origin, the missing TEER development across the cell membrane and the notorious holes observed via immunofluorescence suggest an immature …
Modulation of stemness in a human normal intestinal epithelial …
2014年4月1日 · In our laboratory, we isolated the first normal human intestinal epithelial crypt (HIEC) cell model from the human fetal intestine and in this study we investigated the …
Human crypt intestinal epithelial cells are capable of lipid …
2000年1月1日 · The recent availability of spontaneously proliferating, non-transformed human crypt intestinal epithelial cells (HIEC) affords an opportunity to investigate lipid metabolism in …
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers …
2024年3月10日 · Fraxin treatment exerts radioprotective effects by activating interleukin (IL)–22 in HIEC-6 cells. (A) HIEC-6 cells were pretreated with 160 μM fraxin and 0.1 μg/mL IL-22 …
The development of a functional human small intestinal ... - PubMed
2021年6月2日 · We developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable hIEC progenitors and a functional hIEC monolayer …
功能性人小肠上皮药物吸收模型的建立,Science Advances - X-MOL
需要先进的技术来生成具有细胞多样性和功能的人类肠上皮细胞（hIEC），以预测人类口服药物的吸收并研究正常的肠上皮生理学。 我们开发了一种可重复的两步方案，诱导人类多能干细胞 …
Human small intestinal epithelial cells differentiated from adult ...
As a novel in vitro system for the evaluation of drug absorption, we characterized a human small intestinal epithelial cell (HIEC) monolayer that differentiated from adult ISCs. Continuous …