Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a novel class of oral medications developed for the treatment of anemia in chronic kidney disease (CKD).

促红细胞生成素（EPO）的生成是由低氧诱导因子（HIF）调节，而HIF又是被脯氨酰羟化酶（PH）所调节。 在常氧状态下，HIF-PH的活动将会快速降解HIF；而在低氧条件下，HIF-PH …

缺氧诱导因子(HIF) 是一种关键转录因子,主要参与细胞调节和氧输送效率。 其初步状态包括组成性表达的核结合β 亚基和胞浆α亚基的三种亚型(HIF-1α、HIF-2α 和HIF-3α)。 HIF-1α 和HIF-2 α …

The hypoxia-inducible factor (HIF)–prolyl hydroxylase domain (PHD) pathway regulates cellular responses to hypoxia and is involved in multiple diseases, including anemia, polycythemia, …

Hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) enzyme inhibitors are a new class of agents for the treatment of anemia in CKD. These agents work by stabilizing the HIF complex …

2017年6月1日 · Hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) enzyme inhibitors are a new class of agents for the treatment of anemia in CKD. These agents work by stabilizing the …

In this review, I describe the process of molecular cloning of HIF and HIF-PH, which explains the induction of EPO expression by hypoxia; the development of HIF-PH inhibitors (HIF-PHIs) that …

Introduction: The hypoxia-inducible factor prolyl hydroxylase (HIF-PH) pathway is responsible for regulating the biosynthesis of erythropoietin (EPO) and maintaining iron homeostasis. …

2024年3月8日 · 低氧诱导因子（HIF） 是一种参与细胞调控和氧气输送效率的关键转录因子，由调节亚基HIF-α和结构亚基HIF-β构成，当两个亚基形成复合物时，能够激活下游信号通路并诱导 …

血液中には低酸素誘導因子（HIF：Hypoxia Inducible Factor）と呼ばれる酸素濃度の低下を感知する細胞内の酸素センサー的役割を果たしている物質があるが、慢性腎臓病（CKD）の病態 …