Role and regulation of prolyl hydroxylase domain proteins
2008年2月15日 · Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)- α subunits by prolyl hydroxylase domain (PHD) proteins signals their polyubiquitination and proteasomal...
The Hypoxia-Inducible Factor Pathway (HIF) | Haase Lab
The prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) axis is a critically important oxygen-sensing pathway that mediates tissue adaptation to low oxygen environments …
Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the …
Hypoxia-inducible factor–prolyl hydroxylase domain inhibitors (HIF-PHIs) are a promising new class of orally administered drugs currently in late-stage global clinical development for the …
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic ...
2025年1月18日 · Hypoxia-inducible factors (HIFs) are key transcription factors mediating the activation of many oxygen-dependent genes. HIF activation occurs in many pathological …
Prolyl hydroxylase domain enzymes: important regulators of …
The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in …
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α …
2024年4月18日 · We investigated clinically used PHD inhibitors and a new selective PHD inhibitor (IOX5), to stabilize HIF-α in AML cells. PHD inhibition compromises AML in a HIF-1α …
HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for ...
In this review, I discuss the process of molecular cloning of HIF and HIF-PH, which explains hypoxia-induced EPO expression; the development of HIF-PH inhibitors that artificially or …
Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy ... - PubMed
2018年8月23日 · Prolyl hydroxylase domain (PHD) enzyme inhibition can stabilize hypoxia-inducible factor (HIF). HIF stabilization also decreases hepcidin, a hormone of hepatic origin, …
Inflammation and Hypoxia: HIF and PHD Isoform Selectivity
2019年1月1日 · The links between hypoxia signaling and inflammation are bidirectional: hypoxia may also exacerbate inflammation through activation of inflammatory pathways and effects on …
Inflammation and Hypoxia: HIF and PHD Isoform Selectivity
Cells sense and respond to hypoxia through the activity of the transcription factor HIF (hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain enzymes …