The HIF1 beta subunits (HIF1B), also known as aryl hydrocarbon receptor nuclear translocators (ARNT), are encoded by two genes ARNT1 and ARNT2. HIF1B is stably expressed and is …

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of …

HIF-1β 亚基 又称 芳香烃 受体核转运子 (aryl hydrocarbon re-eptor nuclear translocator,ARNT), 基因定位 于人的 1号染色体 q21区,在细胞内 稳定表达,起结构性作用;HIF-1α基因定位于人的 14 …

HIF-1β，又称 芳香烃受体 核转运因子1 (aryl hydrocarbon receptor nuclear translocator, ARNT1)，分子量86636。 对应的基因位于1号染色体，其中有一个编码15aa的可变外显子， …

2019年6月20日 · Under hypoxia, the activity of PHDs and FIHs are suppressed, and HIF-α subunits translocate into the nucleus to bind with HIF-1β (HIF1B). The heterodimeric HIF-α: …

后生动物已进化出适应缺氧的机制，这种机制受缺氧诱导因子 (HIF) 介导，HIF 是一个异二聚体碱性-螺旋-环-螺旋转录因子家族，由一个 O 2 调节 HIF-α 亚基（HIF-1α、HIF-2α 和 HIF-3α）和 …

2013年4月26日 · Adaptation to low oxygen levels is mediated by the hypoxia-inducible factor (HIF) pathway promoting invasion, metastasis, metabolic alterations, chemo-resistance and …

HIF-α proteins are regulated in an oxygen-dependent manner, whereas ARNT is generally regarded as constitutively expressed, meaning that neither the arnt mRNA nor the protein level …

Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the primary genes …

2011年10月5日 · In the present study, we have evaluated the role of the Hif transcriptional system by creating a mouse lacking Hif1β (Arnt) in adipose tissue. We find that these mice are …