HIKESHI is a protein-coding gene in Homo sapiens. Alternate names for the gene are FLJ43020, HSPC138, HSPC179, and L7RN6. Located on long arm of chromosome 11 at area q14.2, the entire gene including introns and exons is 42,698 base pairs on the plus strand.

2024年12月25日 · HIKESHI (Heat Shock Protein Nuclear Import Factor Hikeshi) is a Protein Coding gene. Diseases associated with HIKESHI include Leukodystrophy, Hypomyelinating, 13 and C11orf73-Related Autosomal Recessive Hypomyelinating Leukodystrophy. Among its related pathways are Cellular responses to stimuli and Cellular response to heat stress.

热休克蛋白核输入因子 hikeshi： 该基因编码一种进化上保守的核转运受体，该受体通过与 FG-核孔蛋白的相互作用介导热休克诱导的 70 kDa 热休克蛋白 (Hsp70s) 的核输入。

2023年11月6日 · Mutation in Hikeshi, encoding a nonconventional nuclear import carrier of heat shock protein 70 family (HSP70s), leads to inherited leukodystrophy; however, the pathological mechanisms remain elusive. Here, we showed that Hikeshi is essential for central nervous system (CNS) myelination.

综上，该项研究揭示了核转运蛋白Hikeshi-HSP70s在中枢神经系统中的生理功能和作用机制，以及热疗可作为缓解髓鞘损伤的有效方法，为脱髓鞘相关疾病的研究和防治提供了新的思路。

2012年4月27日 · Here, we identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein named "Hikeshi," which does not belong to the importin β family. Hikeshi binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers.

2024年12月1日 · “Hikeshi” is a traditional Edo-era Japanese compound word used to refer to firefighters, smoke jumpers, or troubleshooters. The interaction between Hikeshi and Hsp70 is unique, as they appear to recognize each other’s three-dimensional structure.

We provide pathologic evidence for a primary disorder of the myelin in HIKESHI -related leukodystrophy. These findings are consistent with the hypomyelination seen in brain magnetic resonance imaging and with the clinical features of early …

2025年2月8日 · HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC3 cells. Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer

2014年7月18日 · In humans, the heat-induced translocation of HSP70 requires the nuclear carrier protein Hikeshi. In the Arabidopsis genome, only one gene encodes a protein with high homology to Hikeshi, and we named this homolog Hikeshi-like (HKL) protein. In this study, we show that two Arabidopsis HSP70 isoforms accumulate in the nucleus in response to heat ...