2024年12月25日 · HIVEP3 (HIVEP Zinc Finger 3) is a Protein Coding gene. Diseases associated with HIVEP3 include Meckel Syndrome, Type 1 and Autism Spectrum Disorder. Among its related pathways are Gene expression (Transcription) and Autodegradation of the E3 ubiquitin ligase COP1. An important paralog of this gene is HIVEP2.

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence.

2022年12月26日 · Knockdown of HIVEP3 significantly repressed cell proliferation invasion, and enhanced cell apoptosis in HL-60 and THP-1 cells. In addition, HIVEP3 donwreglation could inhibit the TGF-β/Smad signaling pathway.

2024年12月10日 · Title: HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia. HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.

2025年2月8日 · HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia. The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.

2025年2月8日 · Enables DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in bone; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Feb 2025]

Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes.

2022年5月10日 · Co-expressed gene clusters of HIVEP3 were enriched in functional pathways related to AML leukemogenesis, such as ribosome, metabolism, and calcium signaling. Combined with multiple tumorigenesis signaling pathways, we proposed an integrated LASSO model with HIVEP3 and ferroptosis regulators AIFM2 and LPCAT3, to predict the outcome for AML patients.

预测能够使dna结合的转录因子活性增强，特异性结合rna聚合酶ii的顺式调控区域序列。参与rna聚合酶ii调控的转录调控。在dna模板驱动的转录正向调控和骨骼肌细胞分化中起上游或内部调控作用。在细胞核中具有活性。与人类hivep3(hivep锌指3)具有同源性。

HIVEP3的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码的人类免疫缺陷病毒1型增强子结合蛋白家族的一个成员。 该蛋白家族的成员包含多个锌指和富酸（ZAS）结构域和丝氨酸 - 苏氨酸丰富区。 该蛋白质充当转??录因子，并且能够通过结合在靶基因的κB的基序来调节核因子介导的转录。 这种蛋白也结合侧翼免疫球蛋白和T细胞受体的V，D和J区的重组信号序列。 选择性剪接的结果在编码和非编码转录本变体。 [由RefSeq的，2011 …