2024年12月25日 · HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Trichothiodystrophy 7, Nonphotosensitive and Type 1 Diabetes Mellitus.Among its related pathways are TCR Signaling (Qiagen) and Immune response NFAT in immune response.Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding.

HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane.It is located in intracellular vesicles.DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide ...

hla-i和ii不同基因座位上分别编码的基因产物，称之为hla复合体抗原，表达在细胞表面，呈凸起状。 HLA的生物学功能不仅限与诱导同种异体组织或器官移植排斥反应相关，而且参与免疫应答的调控，如MHC限制性、抗原转递、补体产生等。

hla-iii类基因大约包含75个基因，大多数功能不明。 hla-i类（mhc i）和ii类（mhc ii）基因是编码结合和呈递抗原的分子，使细胞毒性t淋巴细胞经抗原结合槽与成熟的hla细胞表面蛋白结合，i类基因主要将抗原呈递给cd8+ t细胞，ii类基因主要将抗原呈递给cd4+ t细胞。

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the ...

HLA-DMB 属于 HLA II 类β链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DMA) 和一条 beta (DMB) 链组成，它们都锚定在膜中。它位于细胞内囊泡中。 DM 通过帮助从肽结合位点释放 CLIP (II 类相关不变链肽) 分子，在 MHC II 类分子的肽加载中起着核心作用。

Relationship between HLA-DMB expression and prognosis of UCEC. (A) the relationship between HLA-DMB expression and clinical outcome of cancers.(B) Kaplan–Meier analysis of overall survival in HPA.(C) Kaplan–Meier analysis of overall survival from TCGA.(D, E) Overall Survival (OS) and Disease Free Survival (DFS) for patients in GEPIA2.(F) A nomogram for predicting the probability of 1-, 2 ...

HLA-DMB: 257: Polymorphism. The following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05, DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:03. Keywords. Technical term #3D-structure; #Proteomics identification; #Reference proteome; Sequence databases. CCDS.

hla-dmb属于hla ii类β链平行基因。这个ii类分子是一个由α(dma)和β(dmb)链组成的异二聚体，两者都锚定在膜中。它位于细胞内囊泡中。dm在mhc ii类分子的肽加载中起着核心作用，帮助从肽结合位点释放clip(类ii相关恒定链肽)分子。ii类分子在抗原呈递细胞（apc：b淋巴细胞，树突状细胞，巨噬细胞）中表达。

1994年4月7日 · These results show that HLA-DMA and -DMB, genes of previously unknown function mapping between HLA-DP and HLA-DQ, are required for the normal assembly of peptides with MHC class II molecules. They suggest that HLA-DMA and -DMB encode subunits of a functional heterodimer which is critical in the pathway of class II antigen presentation.