2024年12月25日 · HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are TCR Signaling (Qiagen) and Immune response NFAT in immune response. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity.

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM.

HLA配型也叫移植配型，HLA基因座位点具有高度多态性，完全相合配型的难度非常高。 根据WHO Nomenclature Committee发表的HLA数据，截至2020年3月，已经发现的HLA -I型与II型等位基因数分别为19587和7302。

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM.

hla-ii类基因包括hla-d家族，主要有hla-dp、hla-dq和hla-dr等，主要分布于b淋巴细胞、巨噬细胞和树突状细胞等专职抗原提呈细胞表面。 HLA-III类基因 大约包含75个基因，大多数功能不明。

2024年6月17日 · Gene target information for HLA-DOB - major histocompatibility complex, class II, DO beta (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

do 通过抑制 hla-dm 来抑制 mhc ii 类分子的肽负载。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 β链约为 26-28 kDa，其基因包含 6 个外显子。

2023年11月23日 · HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM.

hla-dob属于hla ii类β链平行系。这个ii类分子是一个由α(doa)和β链(dob)组成的核心异二聚体，两者都固定在膜上。它位于细胞内囊泡中。do通过抑制hla-dm来抑制mhc ii类分子的肽加载。ii类分子在抗原呈递细胞（apc：b淋巴细胞，树突状细胞，巨噬细胞）中表达。

HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Diseases associated with HLA-DOB include Duodenal Obstruction and Systemic Lupus Erythematosus. Among its related pathways are Hematopoietic cell lineage and G-protein signaling N-RAS regulation pathway.