2024年12月25日 · HLA-DRB5 (Major Histocompatibility Complex, Class II, DR Beta 5) is a Protein Coding gene. Diseases associated with HLA-DRB5 include Hla Modifier and Lymphoma . Among its related pathways are TCR Signaling (Qiagen) and Phosphorylation of …

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

总而言之，研究人员发现ACPA-RA患者外周血中HLA-DRB5+ Plasma B缺乏，IGHG4+ plasma B细胞升高，滑膜组织中HLA-DRB5表达缺乏以及memory B细胞的“抗原处理和提呈”功能受损。

HLA-DRB5 affects type 1 diabetes risk and islet autoantibodies. Brain DNA methylation in HLA-DRB5 was associated with pathological Alzheimer disease. findings indicated that copy number variants of HLA-DRB5 was associated with the risk of systemic lupus erythematosus, and copy number deletion appeared to be protective for SLE.

2021年8月17日 · Furthermore, the HLA-DR15 haplotype (DRB1 / DRB5) conveys an increased risk of developing active disease in ACPA+ RA in a large cohort of patients with treatment-naive RA. Immunohistochemical...

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alp ha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

这个数据库包含了数千种MHC Ⅰ和Ⅱ类分子的信息，包括结合基序、多肽长度分布、磷酸化配体的基序，多重特异性或与X射线晶体学结构的链接。

hla-drb5 属于 hla ii 类β链旁系同源物。 这种 II 类分子是一种异二聚体，由一条 alpha (DRA) 和一条 beta (DRB) 链组成，它们都锚定在膜中。 它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。

HLA-DRB5属于HLA II类β链平行系。 这个II类分子是一个由α（DRA）和β（DRB）链组成的异源二聚体，两者都锚定在膜上。 它通过呈现来自细胞外蛋白的肽发挥作用，在免疫系统中扮演重要角色。 II类分子在抗原呈递细胞中表达。 β链约为26-28 kDa，其基因包含6个外显子。 外显子1编码前导肽，外显子2和3编码两个细胞外结构域，外显子4编码跨膜结构域，外显子5编码胞质尾。 在DR分子中，β链包含指定肽结合特异性的所有多态性。 对于骨髓和肾脏移植，这些多态性的 …

2025年3月14日 · With respect to the HLA-DR component, considering the presence of HLA-DRA alongside various HLA-DRB genes, such as HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5, knocking out only DRB1 could result in ...