Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a keratinization abnormality characterized by small, asymptomatic erythematous papules that leave characteristic punctate bleeding when they become detached.

2019年3月13日 · Hyperkeratosis lenticularis perstans is a rare disorder most commonly affecting middle-aged Caucasians, with a genetic predisposition. What is the Cause of the Disease? The etiology of hyperkeratosis lenticularis perstans is unknown.

2022年10月20日 · Flegel disease or hyperkeratosis lenticularis perstans or HLP, is an autosomal dominant inheritance skin disorder characterized by hyperkeratotic papules distributed on the lower extremities. It is reported that females are more susceptible to hyperkeratosis lenticularis perstans (HLP) than males, which usually occurs within 40 to 50 years of age.

Hyperkeratosis lenticularis perstans (HLP), or Flegel's disease (FD), is a rare disorder of keratinization first described in 1958 by Flegel. HLP is characterized by asymptomatic small papules distributed symmetrically on the dorsal feet and lower part of the legs. It …

Hyperkeratosis lenticularis perstans (HLP) is a rare dermatosis first described in 1958 by Flegel (1). HLP is characterized by 1- to 5-mm, asymptomatic, reddish-brown, keratotic papules occurring most frequently over the dorsa of the feet and the lower parts of …

Keratosis pilaris, Darier disease, follicular lichen planus, skin lesions of scurvy, and other follicular keratotic lesions should be differentiated from HLP. Histopathology from a well-developed lesion shows greatly thickened, compact, strongly eosinophilic horny layer standing out in sharp contrast to the less heavily stained basket-weave ...

2022年10月20日 · Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a rare skin disease presenting with asymptomatic small hyperkeratotic papules. The lesions often appear on the dorsal feet and lower legs, and typically develop after the fourth decade of life.

Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by Bean, 1972).

Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by …

A rare skin disease characterized by usually asymptomatic, hyperkeratotic, reddish-brown papules primarily located on the lower extremities. Histological examination shows lamellar hyperkeratosis with abrupt peripheral basket-weave orthokeratosis, irregular acanthosis, and underlying lichenoid lymphocytic infiltrate.