2015年5月29日 · Human neutrophil antigen 2 (HNA-2) is coded by CD177 gene that involves in human myeloproliferative disorders. HNA-2 expression varies among humans and about 3–5% people lack HNA-2 expression.

Human neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that are mostly expressed on human granulocytes. Antibodies that recognize these epitopes have been associated with neutropenia, transfusion complications, haematopoietic stem cell transplant nonengraftment and renal transplant rejection.

Human neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that are mostly expressed on human granulocytes. Antibodies that recognize these epitopes have been associated with neutropenia, transfusion complications, haematopoietic stem cell transplant nonengraftment and renal transplant rejection.

2018年8月17日 · To date, five HNA systems are assigned, and during the last decades enormous efforts have been undertaken to identify the underlying genes and to characterize the antigens. This review of the literature will provide the current genetic, molecular and functional information on …

Antibodies to human neutrophil alloantigens (HNA) are involved in the pathophysiology of several clinical conditions including transfusion-related acute lung injury (TRALI), alloimmune and autoimmune neutropenia, and febrile nonhemolytic transfusion reactions leading to neutropenia.

2013年9月12日 · In this paper, we developed a bioinformatics tool for typing the HNA antigens from personal human whole-genome sequencing data. The NGS technology was evaluated for its potential in high-resolution HNA typing. Our tool combined with NGS data can produce unambiguous results regardless any new identified variants of the antigen systems.

The molecular basis of each of the five HNA antigen systems has been decoded during the past decades. This enables reliable molecular typing strategies, antibody detection and specification as well as development of new assays based on recombinant antigens.

Antibodies directed against the neutrophil-specific Fcγ receptor IIIb (FcγRIIIb), which bears the HNA-1 antigens, are most frequently implicated in neonatal immune neutropenia and autoimmune neutropenia. HNA-3a alloantibodies are responsible for many severe and fatal TRALI reactions.

328 名健康壮族人进行hna-1~5 的基因分型和多态性研究， 调查了解汉族和壮族人群中hna-1~5 的基因频率多态性分布。 结 果在hna-1 系统，hna-1a 是汉族（0.6893）和壮族（0.7454）人群的高频率等位基因，与欧洲、南美洲、非洲等以hna-1b 为高频率

Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder that manifests as recurrent, episodic, painful brachial neuropathies. A gene for HNA maps to chromosome 17q25.3 where mutations in SEPT9, encoding the septin-9 protein, have ...