Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in …
Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, …
Comparative mechanistic study of RPE cell death induced by …
2023年9月1日 · RPE cell death was induced both in vitro and ex vivo by 4-Hydroxynonenal (4-HNE), a major product of lipid peroxidation, sodium iodate (NaIO3) that has been widely used …
4-HNE induces proinflammatory cytokines of human retinal
Oxidative stress and subsequent chronic inflammation result in dysfunction of the retinal pigment epithelium (RPE) and represent therapeutic targets in the context of age-related macular …
4-羟基-2-壬烯醛 - 维基百科，自由的百科全书
4-羟基-2-壬烯醛（英語： 4-hydroxy-2-nonenal ，或4-Hydroxynonenal，缩写4-HNE或HNE）是一种α,β-不饱和烯醛，是细胞脂质过氧化的主要不饱和烯醛产物，1991年由Esterbauer发现 [2] 。
CFH exerts anti-oxidant effects on retinal pigment epithelial cells ...
2019年9月25日 · Exacerbated oxidative stress in RPE contributes to AMD 8 eliciting decomposition of polyunsaturated fatty acid and the formation of 4-hydroxy-2-nonenal (4 …
不同氧化应激诱导RPE细胞死亡的比较机制研究,Redox Biology - X …
2023年8月6日 · RPE 细胞死亡由 4-Hydroxynonenal (4-HNE)（脂质过氧化的主要产物）和碘酸钠 (NaIO) 诱导，碘酸钠 (NaIO) 已广泛用于模拟干性 AMD 中的 RPE 细胞死亡，这是一种铁死亡 …
4-HNE通过促进HSP70的细胞外排诱导人视网膜色素 ... - X-MOL
氧化应激和随后的慢性炎症导致视网膜色素上皮（rpe）的功能障碍，并在与年龄有关的黄斑变性（amd）的背景下成为治疗靶标。 然而，将氧化应激和炎症联系起来的分子机制仍不清楚。
4-HNE induces proinflammatory cytokines of human retinal …
2019年11月1日 · Arimoclomol, an inducer of HSP70, significantly inhibited 4-HNE-mediated inflammation, indicating that HSP70 may be a potential target for controlling inflammation in …
Age-related macular degeneration and retinal protein ... - PubMed
Purpose: Oxidative damage to proteins, lipids, and DNA has been suggested to be a mechanism for age-related macular degeneration (AMD). The retina is particularly susceptible to lipid …
(PDF) Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE
2022年3月23日 · Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell …