The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating in the motor …

There are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are …

2021年9月24日 · In the neuromuscular system, signal transmission from motor neurons (MNs) to innervated muscle fibers is crucial for their synaptic function, viability, and maintenance. In …

2021年9月1日 · Here we describe a standardized method for engineering an isogenic, patient specific human neuromuscular junction (NMJ) that allows for automated quantification of NMJ …

The knockdown caused degenerated features in the NMJ and muscle, and the NMJ showed functional defects consistent with SMA when stimulated chemically or optogenetically. We …

2020年12月1日 · Here, we describe current models for neural, tendinous, and vascular connections in hSkMTs and their limitations. The NMJ is a synaptic connection wherein …

In order to better understand human neuromuscular junction (hNMJ) functionality, we developed on-a-chip devices to grow hNMJs on a specific electrode pattern to stimulate pre-synaptic …

2017年11月28日 · Here, we combined morphological techniques, super-resolution imaging, and proteomic profiling to reveal the detailed cellular and molecular architecture of the human …

Human NMJs are among the smallest known and release the smallest number of transmitter “quanta”. By contrast, they have the most deeply infolded postsynaptic membranes, which …

There are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are …