Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue...
揭秘HOIP移码变异如何调控NF-κB信号并增强细胞对TNF诱导死亡 …
近日，一项来自华中科技大学和郑州大学的研究揭示了 HOIP （HOIL-1-interacting protein）基因中一个罕见的移码变异如何显著影响人体的免疫系统，为我们理解免疫缺陷疾病提供了新的视 …
Mechanisms underlying linear ubiquitination and implications in ...
2023年11月28日 · Although HOIP and HOIL-1 are both E3 ligases, HOIP is the catalytically active component of LUBAC and the only E3 ubiquitin ligase that can assemble linear ubiquitin. …
The HOIL-1L ligase modulates immune signalling and cell death …
2020年5月11日 · The linear ubiquitin chain assembly complex (LUBAC), which consists of HOIP, SHARPIN and HOIL-1L, promotes NF-κB activation and protects against cell death by …
Site‐specific ubiquitination of the E3 ligase HOIP regulates …
2020年11月20日 · We propose that site‐specific ubiquitination of HOIP regulates a LUBAC‐dependent switch between survival and apoptosis in TNF signaling. The E3 ligase …
HOIP limits anti‐tumor immunity by protecting against combined TNF and ...
2021年9月1日 · HOIP protects tumor cells from apoptosis induced by combined TNF and IFN‐γ co‐secreted by NK and CD8+ T cells. HOIP inhibition might thus be a strategy to enhance …
系统性 HOIP 相互作用组分析揭示线性泛素化在组织稳态中的关键 …
HOIL-1相互作用蛋白（HOIP）是线性泛素化组装复合物的关键组成部分，其催化的线性泛素化通过执行域特异性调节功能在组织稳态中发挥重要作用。 然而，缺乏跨组织的 HOIP 域特异性 …
E3 泛素连接酶 HOIP 减弱顺铂诱导的细胞凋亡。,Cancer Research
在重点 siRNA 筛选中，使用靶向泛素和泛素样信号传导基因的 siRNA 文库，我们将 E3 泛素连接酶 HOIP 鉴定为顺铂诱导的基因毒性的关键调节剂。 HOIP 与 SHARPIN 和 HOIL-1L 形成线 …
Structural Insights into SHARPIN-Mediated Activation of HOIP …
2017年10月3日 · Here, we biochemically and structurally demonstrate that the UBL domain of SHARPIN specifically binds to the UBA domain of HOIP and thereby associates with and …
HOIP limits anti-tumor immunity by protecting against combined …
2021年11月4日 · Both genetic deletion and pharmacological inhibition of HOIP augment tumor cell sensitivity to combined TNF and IFN-γ. Together, we unveil a protective regulatory axis, …
- 某些结果已被删除