2024年1月19日 · Here, we investigated the role of hox13 genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish hox13 paralogs and phenotypes of CRISPR/Cas9-induced mutants showed that double hoxb13a and hoxc13a mutants fail to form a caudal fin.

2024年10月9日 · Our study demonstrates that zebrafish hox clusters, homologous to HoxA and HoxD clusters, which are essential for limb development in mice, also play an important role in the specific skeletal ...

2024年1月19日 · Here, we investigated the role of hox13 genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish hox13 paralogs and phenotypes of CRISPR/Cas9-induced mutants showed that double hoxb13a and hoxc13a mutants fail to form a caudal fin.

2021年2月18日 · Zebrafish with mutations in the waslb/vav2 pathway express limb-like Hox patterning mechanisms that drive the formation of new, fully integrated bones along the length of the fin, revealing in fins the presence of latent developmental programs once thought unique to …

We show that different hox genes regulate dorsal fin development between zebrafish and medaka and may have been transferred during evolution, potentially influencing dorsal fin positions in teleosts. The dorsal and anal fins can vary widely in position and length along the anterior–posterior axis in teleost fishes.

2016年8月17日 · Neil Shubin and colleagues have compared Hox function in fins and limbs by performing cell lineage and knockout assays of Hox genes in zebrafish fins.

Genes in the 5' extremity of the HoxD cluster encode DNA-binding transcription factors essential for development of the autopod and digits, regulating primarily gene expression and, consequently, morphogenesis and skeletal differentiation.

2024年1月19日 · terior Hox genes likely regulate homocercal fin patterning and evo - lution. Hox genes encode homeodomain-containing transcription factors organized into four clusters in tetrapods (12, 13). Their an-teroposterior expression during embryogenesis generally correlates with their genomic organization (17). 14Hox13– paralogs are ex-

Hox genes control homocercal caudal fin development and evolution. The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents...

HoxA genes encode for important DNA-binding transcription factors that act during limb development, regulating primarily gene expression and, consequently, morphogenesis and skeletal differentiation.