Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. [5][6] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development.

2024年12月25日 · HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include Leukemia, Acute Lymphoblastic and Hematologic Cancer. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HMX3.

2024年1月2日 · Here, we perform genome-wide CRISPR/Cas9 screening in the HOXA9-driven reporter acute leukemia cells. We identify a poorly characterized RNA-binding protein, RBM5, as the top candidate gene required to maintain leukemia cell fitness. RBM5 is highly overexpressed in acute myeloid leukemia (AML) patients compared to healthy individuals.

2015年6月1日 · HOXA9 is a homeodomain-containing transcription factor that has an important role in hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A variety of upstream...

2020年6月26日 · HOX9 is an HD-Zip transcription factor that evolved from charophytes and confers stress tolerance. We employed a range of bioinformatics and evolutionary tools to assess HOX9 as a representative protein of the HD-Zip family in plant and algal species (Fig. 4 Supplementary Fig. S4, Supplementary Table S12).

2021年1月22日 · HOX基因簇是胚胎发育的主要调控因子，其中HOXA9基因在血液系统发生和白血病形成过程中发挥重要作用。 如相关研究表明在人类脐带血和人类胚胎干细胞产生的CD34阳性细胞中该基因转录表达差异显著；该基因在人类造血干细胞中高表达，但是在分化过程中被下调；Hoxa9基因敲除小鼠不具有致命的表型，但造血功能显著下降，而且该基因缺陷导致髓样和淋巴样干祖细胞功能的缺陷和异常。 为了进一步阐明HOXA9造血基因的功能，本研究中作者构建 …

HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with anterior–posterior patterning during embryonic development, and its expression is then abolished in most adult cells, with the exception of hematopoietic progenitor cells.

Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in patients. Leukemia subtypes with hallmark overexpression of HOXA9 include those carrying MLL gene rearrangements, NPM1c mutations, and other genetic alternations.

2025年2月8日 · HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma. Han S, et al. Cells, 2019 Oct 31. PMID 31683603, Free PMC Article. HOXA9 rs3801776 G>A polymorphism increases congenital talipes equinovarus risk in a Chinese population. Li J, et al. J Gene Med, 2019 Oct. PMID 31424148.

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。 这些蛋白质的表达在胚胎发育过程中受到时空调控。 该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。 该基因与果蝇的 abdominal-B (Abd-B) 基因高度相似。 导致该基因与 NUP98 基因融合的特定易位事件与骨髓性白血病发生有关。 该基因与上游同源框 A10 (HOXA10) 基因之间存在通读转录。 [RefSeq 提供，2011 年 3 月]