2024年12月25日 · HOXC6 (Homeobox C6) is a Protein Coding gene. Diseases associated with HOXC6 include Placental Choriocarcinoma and Lymphoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is HOXB6.

The HOXC6 isoform, HOXC6-2 is an active carcinogenic for gastric cancer. It stimulates gastric cancer cells proliferation by acting as an oncogene. Downregulation of this gene’s isoforms could potentially lead to less proliferation of certain cancerous cells.

HOXC6通过抑制DKK1分泌激活Wnt/β-catenin通路. 为了探究HOXC6促进DKK1表达和DKK1上调导致Wnt/β-catenin途径的激活机制，作者首先通过qPCR和WB实验验证高通量RNA测序结果，发现DKK1

2024年1月15日 · HOXC6 plays an essential part of the carcinogenesis of solid tumors, but its functional relevance within the immune contexture in patients with colorectal cancer (CRC) is still uncertain.

2024年11月7日 · HOXC6高表达与乳腺癌的发生、发展、预后相关；HOXC6过表达可促进乳腺癌细胞MCF-7增殖，并抑制细胞凋亡。

HOXC6 plays an essential part of the carcinogenesis of solid tumors, but its functional relevance within the immune contexture in patients with colorectal cancer (CRC) is still uncertain. We intended to investigate the predictive value of HOXC6 ...

HOXC6 up-regulates BCL2 expression and promotes cervical cancer progression. Up-regulated HOXC6, in PCa patients, could not only participate in the progression of PCa but also function as an independent prognostic marker for the cancer

2021年4月1日 · We previously found that homeobox C6 (HOXC6) was the most significantly upregulated gene in RCC compared to LCC. However, it remains unclear whether HOXC6 plays a role in tumor...

2022年4月29日 · The biological role of HOXC6 in gliomas was primarily associated with EMT and the immune microenvironment in gliomas. High HOXC6 expression was related to high infiltration by immune cells, a low tumour purity score, a high stromal score, a high immune score and the expression of a variety of immune checkpoint genes, including PD-L1, B7-H3 and ...

哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。 该基因 HOXC6 是位于 12 号染色体簇中的几个 HOXC 基因之一。 三个基因 HOXC5、HOXC4 和 HOXC6 共享一个 5' 非编码外显子。 转录本可能包括与基因特异性外显子剪接的共享外显子，或者它们可能仅包括基因特异性外显子。 已经为 HOXC6 鉴定了编码不同同种型的可变剪接转录物变体。 转录变体二包括共享外显子，转录变体一仅包 …