Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene. [4][5][6] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

2024年12月25日 · HOXC8 (Homeobox C8) is a Protein Coding gene. Diseases associated with HOXC8 include Distal Arthrogryposis and Hematologic Cancer. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

2018年1月17日 · We showed that HOXC8 was upregulated in clinical NSCLC specimens compared to normal lung tissues, and the high expression of HOXC8 correlated with tumor node metastasis (TNM) stage, tumor...

HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression. HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma; HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis.

2024年11月2日 · Title: HOXC8 alleviates high glucose-triggered damage of trophoblast cells during gestational diabetes mellitus via activating TGFβ1-mediated Notch1 pathway. HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.

2024年9月27日 · 同源盒基因C8 (homeobox gene C8,HOXC8)属于同源异型盒基因家族,是一类高度保守的转录因子,普遍存在于包括人在内的脊椎动物基因组之中.HOXC8可通过特异性调控其靶基因的转录参与生物体的多项生命过程.近年来,研究发现HOXC8的异常表达与多种肿瘤的发生发展密切相关.该文从HOXC8的生物学功能及其在消化道肿瘤中的作用进行综述,探讨HOXC8与消化道肿瘤中的作用机制,以期为寻找消化道肿瘤治疗的新靶点提供理论依据.

哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。 该基因是位于 12 号染色体簇中的几个同源框 HOXC 基因之一。 该基因的产物可能在软骨分化的调节中发挥作用。 它还可能与软骨发育不良或其他软骨疾病有关。 [RefSeq 提供，2008 年 7 月] This gene belongs to the homeobox family of genes.

2017年2月16日 · The candidate gene HOXC8 epigenetic regulation was studied by DNA methylation and miRNA expression analyses. Self-renewal and differentiation of HOXC8-overexpressing or knockdown cells were assessed by flow cytometry and mammosphere, 3D matrigel and soft agar assays.

同源盒基因C8 (homeobox gene C8,HOXC8)为同源异型盒基因(homeobox genes,HOX)家族成员之一,是一类在进化上高度保守的转录因子,在家畜及人类等脊椎动物中普遍存在.HOXC8基因作为转录因子可与靶基因位点发生特异性结合,激活或抑制相关基因转录,从而参与调控生物体的多项 ...

2023年10月20日 · HOXC8 overexpression was associated with poor prognosis and specific TME subtypes in CRC. This study provided valuable resource for further exploring the potential mechanisms and therapeutic targets of HOX genes in CRC.</span>