肿瘤表观遗传第二讲——组蛋白甲基化 - 知乎
HP1蛋白HP1α (CBX5)、HP1β (CBX1)和HP1γ (CBX3)含有甲基赖氨酸结合的染色体结构域，在异染色质形成中发挥重要作用。 SUV39H1催化的组蛋白H3K9的甲基化为HP1蛋白创造了一个结 …
Mechanisms Underlying the Regulation of HP1γ by the NGF …
2018年10月10日 · Heterochromatin protein 1 γ (HP1γ) is a well-known chromatin protein, which regulates gene silencing during the execution of processes associated with embryogenesis, …
Nat Commun | 天津医科大学刘志强团队揭示HP1γ乙酰化修饰促进 …
进一步研究发现，HDAC1对HP1γ K5位点去乙酰化修饰是促进HP1γ蛋白稳定和核内凝聚状态的重要原因。 HP1γ的CSD结构域可以与DNA损伤修复蛋白MDC1结合，通过DNA损伤修复促 …
Deacetylation induced nuclear condensation of HP1γ promotes
2023年3月9日 · Our findings elucidate a previously unrecognized role of HP1γ in inducing drug resistance to proteasome inhibitors of myeloma cells and suggest that targeting HP1γ may be …
Mouse HP1γ regulates TRF1 expression and telomere stability
2023年10月15日 · We investigated the telomere function of HP1γ by using HP1γ deficient mouse embryonic fibroblasts (MEFs). We used gene expression analysis of HP1γ deficient MEFs and …
Heterochromatin Protein 1γ Epigenetically Regulates Cell ...
2009年1月1日 · Here, we have identified a novel function of HP1γ in the process of cell differentiation with the methylation of histone H4 K20. We also observed the dissociation of the …
HP1γ regulates H3K36 methylation and pluripotency in
2020年12月16日 · HP1γ-deleted ESCs have a slower self-renewal rate and an impaired ability to differentiate towards cardiac mesoderm. Our findings reveal a requirement for HP1γ in faithful …
HP1γ binding pre-mRNA intronic repeats modulates RNA splicing …
2021年9月6日 · We find that HP1γ is specifically targeted to hexameric RNA motifs and coincidentally transposable elements of the SINE family. As these elements are abundant in …
Mechanisms Underlying the Regulation of HP1γ by the NGF …
2018年10月10日 · Heterochromatin protein 1 γ (HP1γ) is a well-known chromatin protein, which regulates gene silencing during the execution of processes associated with embryogenesis, …
Discovery, expression, cellular localization, and molecular ... - PLOS
2020年2月6日 · Here, we used a combination of bioinformatics-based methodologies, as well as experimentally-derived datasets, that reveal the existence of a novel short HP1γ (CBX3) …
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