Hereditary persistence of fetal hemoglobin (HPFH) is a condition with significant fetal hemoglobin (HbF) production which continues in adulthood. This is usually caused by mutations in the β- or α-globin gene cluster or the γ promoter gene region.

Hereditary Persistence of Fetal Hemoglobin (HPFH) is a rare benign asymptomatic genetic disorder where the HbF persists, and incidentally discovered on screening for other hemoglobinopathies. In adults, the variation in HbF levels could also be associated with other disease states, including hemoglobinopathies, leukemias and bone marrow failure ...

We studied 30 cases of HbS-HPFH (types 1 and 2), confirmed by molecular analysis, and report the haematological features and change in HbF levels over time.

2018年6月1日 · In this report we described a rare case of compound heterozygous mutation of South-East Asia type hereditary persistence of fetal hemoglobin (SEA-HPFH) and β -thalassemia that allowed prenatal diagnosis to be performed in a subsequent pregnancy in the family.

THE "hereditary persistence of fetal hemoglobin" (HPFH) has received increasing attention since its first detection by Edington and Lehmann. 1 In this benign condition, the heterozygote has 10 to...

Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.

遗传性持续性胎儿血红蛋白增高症 （ Hereditary persistence of fetal hemoglobin ， HPFH ）是成人红细胞中 持续存在过量的 胎儿血红蛋白 (Fetal hemoglobin ， Hb F) ，血液学检查正常的遗传综合征。携带者常无临床症状。

This report describes a case of hereditary persistence of fetal hemoglobin (HPFH) presenting initially as a marginal placental abruption in a primiparous woman at 27 weeks gestation. Persistent but erratic elevation of percent hemoglobin F positive cells, as determined by a modified Kleihauer-Betke …

2020年7月1日 · A new form of hereditary persistence of fetal hemoglobin (HPFH) producing 3%-8% Hb F in heterozygotes and an elevation of F-cell counts as measured by both the Kleihauer test and an antibody ...

2014年11月14日 · Case: A 50 years male, father of a β-thalassemia major patient, reported having Fetal Hemoglobin, 94.90% without any symptoms while being investigated for his family status of thalassemia.