2024年12月25日 · HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) and Fatty acid metabolism.

THE CRIPPLER - I'm Just Gonna Let Myself In. 1. Fresh Out Of Flesh. Sign up to get the latest news on pre-orders, new releases, sales and more...

2010年3月4日 · 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. The anabolic pathways of prostaglandins are well-characterized, especially with respect to regulation of the cyclooxygenase (COX) enzymes.

2025年2月8日 · 15-hydroxyprostaglandin dehydrogenase provided by HGNC. HGNC:HGNC:5154. Ensembl:ENSG00000164120 MIM:601688; AllianceGenome:HGNC:5154. protein coding. REVIEWED. PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1. This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family.

2020年7月23日 · By catalyzing the conversion of the 15-hydroxyl group of prostaglandins into a keto group, this ubiquitous enzyme strongly reduces the biologic activity of these molecules.

The data indicate that HPGD-mediated suppression is a tissue- and context-dependent suppressive mechanism used by Regulatory T cells to maintain adipose tissue homeostasis. We describe for the first time an association between maternal smoking and HPGD expression.

2025年2月23日 · Prostaglandin regulation is known to play a pivotal role in tumorigenesis; however, the contributions of the prostaglandin-metabolizing enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) to cancer development remain poorly understood.

15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2α) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2).

2019年5月21日 · Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which catabolizes prostaglandin E 2 (PGE 2) into the metabolite 15-keto PGE 2, was highly expressed in Treg cells, particularly those in visceral adipose tissue (VAT).

2024年6月6日 · HPGD encodes 15-Hydroxyprostaglandin dehydrogenase catalyzing the decomposition of prostaglandin E2 and has not been reported in multiple sclerosis (MS). We previously found that Nr4a1 regulated microglia polarization and inhibited the progression of experimental autoimmune encephalomyelitis (EAE).