2023年8月8日 · Hepatorenal syndrome (HRS) is a multiorgan condition affecting the kidneys and the liver. It is a cause of acute kidney injury that can be seen in those with acute or chronic liver disease. The first association of renal failure in cirrhosis was observed in the late 1800s.

Type I HRS (HRS-1) is characterized by an abrupt deterioration in renal function (in less than 2 weeks), defined by a doubling of baseline sCr to >2.5 mg/dL or a 50% reduction in the initial 24 hrs creatinine clearance to <20 mL/min. Frequent precipitating events leading to HRS-1 are bacterial infections, gastrointestinal hemorrhage, or large ...

2021年3月3日 · Type 1 hepatorenal syndrome (HRS-1) is a condition of rapidly progressing kidney failure that occurs in patients with decompensated cirrhosis and ascites. 1,2...

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is one of many potential causes of acute kidney injury in patients with cirrhosis and ascites. HRS-AKI is a diagnosis of exclusion and is associated with a poor prognosis if left untreated. This topic will review the clinical presentation and diagnosis of HRS-AKI.

Hepatorenal syndrome (HRS) can occur in patients with cirrhosis and ascites due to splanchnic vasodilation, renal hypoperfusion, and vasoconstriction. HRS is a diagnosis of exclusion and portends a poor prognosis, with upward of 80% mortality at 2 weeks without treatment.

Hepatorenal syndrome type 1 (HRS-1) is a serious form of AKI that affects individuals with advanced cirrhosis with ascites. Prompt and accurate diagnosis is essential for effective implementation of therapeutic measures that can favorably alter its ...

2021年7月15日 · HRS is a functional syndrome characteristically devoid of parenchymal and structural kidney damage. Thus, urinary biomarkers show promise in distinguishing HRS-AKI from acute tubular necrosis (ATN). The deterioration of kidney function springs from the hemodynamic changes brought about by the cirrhotic liver.

2018年3月1日 · We aimed to determine if pentoxifylline (PTX) therapy in addition to the standard of care of volume expansion with albumin and vasoconstriction with midodrine and octreotide (AMO) is safe and efficacious compared to AMO in HRS-1 treatment.

Hepatorenal syndrome type 1 (HRS-1) is a unique form of acute kidney injury that affects individuals with decompensated cirrhosis with ascites. The primary mechanism leading to reduction of kidney function in HRS-1 is hemodynamic in nature. Cumulative evidence points to a cascade of events that led …

2020年7月18日 · 1型肝肾综合征（HRS-1）是一种急性危及生命的综合征，在肝硬化患者导致快速进行性急性肾功能衰竭，如果不进行治疗，该病的中位生存时间约为2周 ...