2024年12月25日 · HSD17B4 (Hydroxysteroid 17-Beta Dehydrogenase 4) is a Protein Coding gene. Diseases associated with HSD17B4 include Perrault Syndrome 1 and D-Bifunctional Protein Deficiency. Among its related pathways are Peroxisomal lipid metabolism and Bile acid and bile salt metabolism.

The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998).

23 小时之前 · HSD17B4 deficiency disrupts peroxisomal metabolism and causes ciliopathy-like phenotypes. Here the authors show that acetyl-CoA restores primary cilia and improves cerebellar defects in Hsd17B4 ...

In HEK293 cells, the D-bifunctional protein (HSD17B4) and the peroxisomal ABC transporter ABCD3 are essential in peroxisomal oxidation of lauric and palmitic acid. HSD17B4 overexpression increased STAT3 activation. This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation.

该基因中影响过氧化物酶体脂肪酸 β-氧化活性的缺陷是 D-双功能蛋白缺乏症 (DBPD) 的一个原因。 该基因的明显假基因存在于 8 号染色体上。 已发现该基因编码不同同种型的多个可变剪接转录物变体。 [RefSeq 提供，2014 年 5 月] The protein encoded by this gene is a bifunctional Enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids.

The HSD17B4 gene provides instructions for making the D-bifunctional protein. This protein is an enzyme, which means that it helps specific biochemical reactions take place. D-bifunctional protein is so named because it aids in two biochemical reactions.

2025年2月9日 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) expression by HIV-1 Vpr in Vpr transduced macrophages

The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998).

HSD17B4 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence). HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids and as a …

The HSD17B4 gene codes for a 80 kDa multifunctional enzyme containing three distinct functional domains and is localized in peroxisomes. The N-terminal part exhibits 3-hydroxyacyl-CoA dehydrogenase and 17beta-hydroxysteroid dehydrogenase activity whereas the central part shows enoyl-CoA hydratase ac …