Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the HSPA8 gene on chromosome 11. [5] As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as ...

2024年12月25日 · HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Auditory System Disease and Borna Disease. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Selective autophagy.

2023年8月14日，中国科学院分子细胞科学卓越创新中心孙丽明团队在Cell Research 在线发表了题为“HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation”的研究论文，该研究确定 热休克蛋白家族A成员8 （HSPA8）是一种新型酶，称 …

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization. FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression. Hspa8 and ICAM-1 as damage-induced mediators of gammadelta T cell activation.

2023年8月14日 · Here, we identify heat shock protein family A member 8 (HSPA8) as a new type of enzyme — which we name as ‘amyloidase’ — that directly disassembles RHIM-amyloids to inhibit necroptosis signaling...

HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. In particular, its regulatory role in autophagy is decisive. We focused this review on HSC70 structure-function consider …

HSPA8 is a crucial molecular regulator of chaperone-mediated autophagy, as a detector of substrates that will be processed by this specialized autophagy pathway. In this review, we shortly summarize its structure and overall functions, dissect its implication in immune disorders, and list the known pharmacological tools that modulate its functions.

该基因编码热休克蛋白 70 家族的一个成员，该家族包含热诱导和组成型表达的成员。 这种蛋白质属于后一组，也称为热休克同源蛋白质。 它起到伴侣的作用，并与新生多肽结合以促进正确折叠。 在细胞膜成分转运过程中，它还充当 ATP 酶，分解网格蛋白包被的囊泡。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2011 年 8 月] This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed …

2025年2月8日 · HSPA8 Activates Wnt/beta-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation. HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation.

2023年8月9日 · 热休克蛋白a家族成员8(hspa8)在应激状态下参与错误折叠蛋白的折叠或降解，在癌症中起关键作用。 本研究旨在探讨HSPA8在肝癌发生发展中的作用。