2021年9月6日 · Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4 CRBN E3 ubiquitin ligase, induces cancer cell death by targeting key neo-substrates for degradation....

Cereblon is a protein that in humans is encoded by the CRBN gene. [5] The gene that encodes the cereblon protein is found on the human chromosome 3 , on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394.

Drug binding leads to a change in substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, while no such change is observed in rodents. 1 publication Sequence similarities Belongs to the CRBN family .

Cereblon (CRBN) is a substrate recognition protein in the E3-ligase ubiquitin complex. The binding target of CRBN varies according to tissues and cells, and the protein regulates various biological functions by regulating tissue-specific targets. As new endogenous targets of CRBN have been identifie …

2018年11月13日 · To overcome this difficulty, we generated humanized cereblon (CRBN I391V) mice thereby providing an animal model to unravel complex mechanisms of action in a murine physiological setup. In our current study, we investigated the degradative effect toward IKZF1 and CK-1α, a target substrate of IMiDs.

2021年9月22日 · Cereblon (CRBN) is a substrate recognition protein in the E3-ligase ubiquitin complex. The binding target of CRBN varies according to tissues and cells, and the protein regulates various biological functions by regulating tissue-specific targets.

CRBN, a 442-amino acid protein with multifunction, locates in the cytoplasm, nucleus, and peripheral membrane of the human brain and other tissues . The diverse roles of CRBN on cell metabolism and disease genesis have been extensively studied.

2024年12月24日 · CRBN (Cereblon) is a Protein Coding gene. Diseases associated with CRBN include Intellectual Developmental Disorder, Autosomal Recessive 2 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Infectious disease and SARS-CoV-2 Infection.

2025年2月20日 · To tackle this, we engineer an intermediate human CRBN construct (CRBN_ΔHBD), that contains all important structural regions for compound binding, and purify from a simple, convenient E. coli expression system. We develop several binary and ternary interaction assays and show highly desirable properties of CRBN_ΔHBD for the evaluation of ...

2019年1月25日 · Cereblon (CRBN) is the substrate receptor of the cullin 4-RING E3 ligase complex and has been employed for targeted protein degradation in the treatment of cancers.