Nature重磅揭示Tregs力量！ - 知乎 - 知乎专栏
自 1995 年首次描述，调节性 T 细胞 （Treg） 领域迅速扩大，已发现 Treg 在各种环境中发挥着关键作用，包括自身免疫性疾病、癌症和移植。 为了更好地了解 Treg 介导的作用，已经开发了 …
Conserved human effector Treg cell transcriptomic and epigenetic ...
2021年5月11日 · Our data demonstrate that human inflammation-derived Treg cells acquire a conserved and specific eTreg cell profile guided by epigenetic changes, and fine-tuned by …
Single cell suppression profiling of human regulatory T cells
2025年2月3日 · Single-cell suppression profiling of human Tregs (scSPOT) is based on altering the number of Tregs present in total PBMCs and assay by a 52-marker CyTOF panel …
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in ...
2019年2月19日 · Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. …
Optimizing human Treg immunotherapy by Treg subset selection …
2018年1月11日 · Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tregs. Unlike highly suppressive but …
Defining Human Regulatory T Cells beyond FOXP3: The Need to …
2024年5月30日 · Regulatory T cells (Tregs) are essential to maintain immune homeostasis by promoting self-tolerance. Reduced Treg numbers or functionality can lead to a loss of …
Deciphering Novel Communication Patterns in T Regulatory Cells …
2025年3月18日 · Taken together, a significant proportion of studies have addressed the basic biology of human Tregs in age but do not address the complex interactions of Treg with other …
Human FOXP3+ T regulatory cell heterogeneity - PMC
2018年1月30日 · FOXP 3‐expressing CD 4 + T regulatory (Treg) cells are instrumental for the maintenance of self‐tolerance. They are also involved in the prevention of allergy, allograft …
Expanding the engineered Treg multiverse: Molecular Therapy
2025年3月5日 · Regulatory T cells (Tregs), a rare subset of immune cells tasked with maintaining immune homeostasis, have emerged as a promising cellular therapy for autoimmune disease, …
Long non-coding RNA BCYRN1 promotes cardioprotection by enhancing human ...
3 天之前 · Regulatory T (Treg) cells modulate immune responses and attenuate inflammation. Extracellular vesicles from human cardiosphere-derived cells (CDC-EVs) enhance Treg …