2005年9月23日 · The Class IA phosphatidylinositol (PI) 3-kinase plays a well recognized role in the regulation of S6K1. We now present evidence that the Class III PI 3-kinase, hVps34, also …

Recent studies have shown that the nutrient input to the mTOR Complex1/S6K1 signaling pathway is mediated by class 3 PI3K or hVps34, the oldest member of the PI3K family. …

2008年2月15日 · The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first described as a component of the vacuolar sorting system in Saccharomyces …

2007年4月1日 · hVps34 is known to play a critical role in autophagy, and has been shown to directly interact with the autophagic gene beclin. Beclin was first identified as a Bcl-2 …

Our data suggest that hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1. p70 S6 kinase (S6K1) 2 regulates protein synthesis, cell …

我们的发现凸显了hVps34-SGK3途径的重要性，并暗示了它代表了一种抑制PI3K / Akt信号转导的机制。 数据支持靶向Akt和SGK作为癌症治疗剂的潜力。 EN

2008年5月7日 · AAs appear to mediate this response through class III phosphatidylinositol 3-kinase (PI3K), or human vacuolar protein sorting 34 (hVps34), rather than through the …

We now present evidence that the Class III PI 3-kinase, hVps34, also regulates S6K1, and is a critical component of the nutrient sensing apparatus.

Recent studies have shown that mammalian hVps34 is required for the activation of the mTOR (mammalian target of rapamycin)/S6K1 (S6 kinase 1) pathway, which regulates protein …

We demonstrate that the rise in [Ca 2+]i increases the direct binding of Ca 2+ /CaM to an evolutionarily conserved motif in hVps34 that is required for lipid kinase activity and increased …