2024年12月25日 · HYAL2 (Hyaluronidase 2) is a Protein Coding gene. Diseases associated with HYAL2 include Hyal2 Deficiency and Cleft Lip And Palate-Craniofacial Dysmorphism …

It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI …

Hyaluronidase 2 (HYAL2) is a membrane-anchored protein that is proposed to initiate the degradation of hyaluronan (HA) in the extracellular matrix. The distribution of HYAL2 in …

我们推测 Hyal2，通过与 CD44 的直接相互作用以及可能需要酸性病灶的一些细胞周透明质酸酶活性，抑制糖萼的形成或稳定性，调节 ERM 相关的细胞骨架相互作用，并减少细胞运动。

2015年10月29日 · Hyaluronidase 2 (HYAL2) is a membrane-anchored protein that is proposed to initiate the degradation of hyaluronan (HA) in the extracellular matrix. The distribution of …

HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families. our data uncover a previously unsuspected mechanism of how hyaluronan …

Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a …

2017年1月12日 · HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated …

这种透明质酸酶充当致癌病毒 Jaagsiekte 绵羊逆转录病毒的受体。 该基因是染色体 3p21.3 区域与肿瘤抑制相关的几个相关基因之一。 该基因编码两个选择性剪接的转录本变体，它们仅在 5' …

2001年12月1日 · Hyal2 enzymes have an acidic pH-optimum with an activity that is considerably lower than observed for other types of hyaluronidases. Originally considered to be a typical …