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2023年1月10日 · prc2复合物的晶体结构表明，eed与h3k27me3的结合变构激活了ezh2上刺激响应基序 (srm) 的构象变化，从而提高了其催化效率。 自2017年诺华报道了首个EED抑制剂EED226后，近5年来有多个EED抑制剂被发现。