Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD.

2020年11月1日 · Oxidative stress is a key feature of Inflammatory Bowel Disease (IBD). However, there is still insufficient understanding of the redox architecture that defines the pathogenic mechanisms that link oxidative stress to IBD.

由于零价钼原子的强还原作用，zvmns 可以有效清除 ros 并重塑硫酸葡聚糖钠 (dss) 诱导的 ibd 小鼠模型中的炎症微环境。 体外和体内实验都证实了 ZVMNs 的治疗效果。

2022年8月24日 · 活性氧(ROS)的过度产生是炎症性肠病(IBD)的一个重要病理特征，是导致信号转导失调、炎症反应和DNA损伤的直接诱因。 ROS过度堆积是IBD病理过程中的核心环节，直接加速病程发展和恶化。 因此，清除ROS已成为一种行之有效的IBD治疗策略。 但是，正常水平的ROS 在维持细胞的信号转导具有重要的生理意义。 综合上述双重因素，抗氧化剂用于IBD治疗需要在特定部位的特定细胞内发挥作用，非靶向的抗氧化疗法不仅无效，还会影响其他细胞的生理平衡 …

This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response.

2024年5月7日 · This nanostructure demonstrates efficacy in eliminating ROS within cells closely associated with IBD, diminishing inflammation, and ameliorating disorders in gut microbiota, as evidenced in an IBD mouse model.

2024年2月29日 · 炎症性肠病(ibd)是一种慢性复发性炎症性疾病包括克罗恩病（cd）和溃疡性结肠炎（uc）。ibd的病因复杂不明，与多种致病因素有关，主要包括遗传因素、肠道菌群失调、免疫系统失调、肠道屏障损伤等，因此目前仍无法彻底治愈。

2025年1月1日 · Oxidative stress that is induced by excessive reactive oxygen species (ROS) is considered to be a key pathophysiological mechanism of inflammatory bowel disease (IBD), and restoring redox homeostasis in the inflammatory region by eliminating ROS is …

Oxidative stress caused by ROS overproduction can contribute to the pathogenesis of IBD by damaging cellular components, activating proinflammatory signaling pathways, and impairing the intestinal epithelial barrier.

2025年2月5日 · This review discusses the application of various ROS-responsive nanomaterial delivery systems in IBD therapy, highlights current challenges, and outlines future research directions. Furthermore, we explore the "layered programmable delivery" strategy, which combines ROS-responsive nanoparticles with pH-responsive and cell membrane-targeted ...