经典重读丨Nature肿瘤中IDH1突变和2-HG - 知乎 - 知乎专栏
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase
2015年7月16日 · Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG …
- 作者: An Ping Lin, Saman Abbas, Sang Woo Kim, Sang Woo Kim, Manoela Ortega, Hakim Bouamar, Yissela Escobed...
- Publish Year: 2015
Science | 肿瘤代谢物D-2HG削弱附近的免疫细胞 - 知乎
肿瘤医生应该知道的生物标志物之：IDH1/IDH2 - 知乎
idh1 /2是与细胞代谢相关的基因，发生突变后参与肿瘤的发生发展。 检测其是否发生突变可以针对性的指导靶向治疗，同时该指标还对 急性髓系白血病 以及 神经胶质瘤 有预后提示作用。. idh1/ idh2 生物学作用 idh1和idh2分别编码 异柠檬酸 …
D-2HG comes out of its shell: Metabolic effects on the …
2022年12月1日 · Oncogenic IDH mutants gain the ability to produce D-2-hydroxyglutarate (D-2HG), a metabolite that accumulates to millimolar concentrations in IDH-mutant tumors but is largely absent in IDH-wild-type cells.
Serum D‐2‐hydroxyglutarate and the ratio of …
2023年6月19日 · This study investigates whether serum D-2HG (D-2-hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D-2HG …
The implications of IDH mutations for cancer development and …
2021年6月15日 · D-2HG-restorative second-site IDH mutations are rare; however, mutant IDH-independent elevations in D-2HG levels have been observed in IDH-wild-type breast …
Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2 …
D-2-hydroxyglutarate is an intercellular …
IDH mutation associated with significantly reduced complement activation and decreased numbers of tumor-infiltrating CD4 + and CD8 + T cells with comparable FOXP3 + /CD4 + ratios. D 2 …
A genetically encoded fluorescent sensor enables …
2 天之前 · In this study, we present a first-generation genetically encoded fluorescent sensor that is specific for D-2-HG compared to other structurally similar metabolites and demonstrates a greater affinity for D-2-HG over L-2 …
